Association of sarcopenia and its defining components with the degree of cognitive impairment in a memory clinic population

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Association of sarcopenia and its defining components with the degree of cognitive impairment in a memory clinic population

Larsson, Liss Elin (författare): Karolinska University Hospital, Stockholm, Sweden; The Swedish School of Sport and Health Science, GIH, Stockholm, Sweden

Wang, Rui (författare): Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden;The Swedish School of Sport and Health Science, GIH, Stockholm, Sweden;Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

Cederholm, Tommy (författare): Karolinska University Hospital, Stockholm, Sweden;Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden

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Wiggenraad, Fleur (författare): Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden;Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden

Rydén, Marie (författare): Karolinska University Hospital, Stockholm, Sweden

Hagman, Göran (författare): Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden;Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden

Hellénius, Mai-Lis (författare): Department of Medicine, Karolinska Institutet, Stockholm, Sweden

Kivipelto, Miia (författare): Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden;Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden;Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland;The Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, United Kingdom

Thunborg, Charlotta, 1965- (författare): Högskolan i Gävle,Med-Vårdvetenskap,Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden;Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden;Mälardalen University Department of Health and Welfare, Sweden

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IOS Press, 2023
2023
Engelska.
Ingår i: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 96:2, s. 777-788

Relaterad länk:: https://doi.org/10.3...; visa fler...; https://hig.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.3...; visa färre...

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Background: Sarcopenia and cognitive impairment are two leading causes of disabilities.Objective: The objective was to examine the prevalence of sarcopenia and investigate the association between sarcopenia diagnostic components (muscle strength, muscle mass, and physical performance) and cognitive impairment in memory clinic patients.Methods:368 patients were included (age 59.0±7.25 years, women: 58.7%), displaying three clinical phenotypes of cognitive impairments, i.e., subjective cognitive impairment (SCI, 57%), mild cognitive impairment (MCI, 26%), and Alzheimer’s disease (AD, 17%). Sarcopenia was defined according to diagnostic algorithm recommended by the European Working Group on Sarcopenia in Older People. Components of sarcopenia were grip strength, bioelectrical impedance analysis, and gait speed. They were further aggregated into a score (0–3 points) by counting the numbers of limited components. Multi-nominal logistic regression was applied.Results: Probable sarcopenia (i.e., reduced grip strength) was observed in 9.6% of the patients, and 3.5% were diagnosed with sarcopenia. Patients with faster gait speed showed less likelihood of MCI (odds ratio [OR]: 0.24, 95% confidence interval [CI]: 0.06–0.90) and AD (OR: 0.12, 95% CI: 0.03–0.60). One or more limited sarcopenia components was associated with worse cognitive function. After adjusting for potential confounders, the association remained significant only for AD (OR 4.29, 95% CI 1.45–11.92).Conclusion: The results indicate a connection between the sarcopenia components and cognitive impairments. Limitations in the sarcopenia measures, especially slow walking speed, were related to poorer cognitive outcomes. More investigationsare required to further verify the causal relationship between sarcopenia and cognitive outcomes.

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Av författaren/redakt...: Larsson, Liss El ...; Wang, Rui; Cederholm, Tommy; Wiggenraad, Fleu ...; Rydén, Marie; Hagman, Göran; visa fler...; Hellénius, Mai-L ...; Kivipelto, Miia; Thunborg, Charlo ...; visa färre...

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Association of sarcopenia and its defining components with the degree of cognitive impairment in a memory clinic population

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