Improving cardiorespiratory fitness protects against inflammation in children: the IDEFICS study

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Improving cardiorespiratory fitness protects against inflammation in children : the IDEFICS study

González-Gil, Esther M. (author): Department of Biochemistry and Molecular Biology II, Instituto de Nutrición y Tecnología de los Alimentos, Center of Biomedical Research (CIBM), Universidad de Granada, Spain ; GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, Spain ; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain

Santaliestra-Pasías, Alba M. (author): GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, Zaragoza, Spain ; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain ; Instituto Agroalimentario de Aragón (IA2), Zaragoza, Spain ; Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain

Buck, Christoph (author): Leibniz Institute for Prevention Research and Epidemiology—BIPS, Bremen, Germany

Gracia-Marco, Luis (author): GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, Zaragoza, Spain ; PROFITH (PROmoting FITness and Health through physical activity) Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Spain

Lauria, Fabio (author): Institute of Food Sciences, National Research Council, Avellino, Italy

Pala, Valeria (author): Epidemiology and Prevention Unit, Fondazione IRCCS—Istituto Nazionale dei Tumori, Milan, Italy

Molnar, Denes (author): Department of Pediatrics, Medical School, University of Pécs, Hungary

Veidebaum, Toomas (author): National Institute for Health Development, Center of Health and Behavioral Science, Tallinn, Estonia

Iacoviello, Licia (author): Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy ; Department of Medicine and Surgery, Research Center in Epidemiology and Preventive Medicine (EPIMED), University of Insubria, Varese, Italy

Tornaritis, Michael (author): Research and Education Institute of Child Health, Strovolos, Cyprus

Eiben, Gabriele (author): Högskolan i Skövde,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Medborgarcentrerad hälsa MeCH, Research on Citizen Centered Health, University of Skövde (Reacch US)

Lissner, Lauren, 1956 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine

Schwarz, Heike (author): Leibniz Institute for Prevention Research and Epidemiology—BIPS, Bremen, Germany

Ahrens, Wolfgang (author): Leibniz Institute for Prevention Research and Epidemiology—BIPS, Bremen, Germany ; Institute of Statistics, Bremen University, Germany

De Henauw, Stefaan (author): Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Belgium

Fraterman, Arno (author): Laboratoriumsmedizin Dortmund, Eberhard & Partner, Dortmund, Germany

Moreno, Luis A. (author): GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, Zaragoza, Spain ; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain ; Instituto Agroalimentario de Aragón (IA2), Zaragoza, Spain ; Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain

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2021-04-09
2022
English.
In: Pediatric Research. - : Springer Nature. - 0031-3998 .- 1530-0447. ; 91:3, s. 681-689

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; https://gup.ub.gu.se...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Muscular and cardiorespiratory fitness (MF and CRF) have been related to inflammation. Thus, the aim of this study was to assess the relationship between fitness and high-sensitivity C-reactive protein (hs-CRP) in European children both in the cross-sectional and longitudinal analysis. Methods: Three hundred and fifty-seven children (46.2% males) aged 2–9 years with hs-CRP measured, data from MF and CRF, diet quality, objectively measured physical activity (PA) and screen time at baseline and follow-up after 2 years were included. Body mass index z-score (zBMI), waist circumference (WC) and fat mass index (FMI) were assessed. MF and CRF were also dichotomized as follows: low-medium quartiles (Q1–Q3) and highest quartile (Q4). Results: At follow-up, children with the highest CRF (Q4) showed a lower probability of having high hs-CRP. In the longitudinal analysis, children who improved their CRF over time showed a significantly lower probability (p < 0.05) of being in the highest hs-CRP category at follow-up, independently of the body composition index considered: odds ratio (OR) = 0.22 for zBMI, OR = 0.17 for WC, and OR = 0.21 for FMI. Conclusions: Improving CRF during childhood reduces the odds of an inflammatory profile, independently of body composition and lifestyle behaviours. These highlight the importance of enhancing fitness, especially CRF, to avoid an inflammatory state in children. Impact: Improvements in the cardiorespiratory profile during childhood could reverse an unfavourable inflammatory status.There is a longitudinal and inverse association between CRF and inflammation in children.This is the first longitudinal study assessing the relationship between fitness and inflammation during childhood that takes also into account the lifestyle behaviours.Results from the present study suggest a protective role of fitness already in childhood.Efforts to improve fitness in children should be aimed at as inflammation could trigger future cardiovascular disease.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)

Keyword

Research on Citizen Centered Health, University of Skövde (Reacch US)
Medborgarcentrerad hälsa (Mech)

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By the author/editor: González-Gil, Es ...; Santaliestra-Pas ...; Buck, Christoph; Gracia-Marco, Lu ...; Lauria, Fabio; Pala, Valeria; show more...; Molnar, Denes; Veidebaum, Tooma ...; Iacoviello, Lici ...; Tornaritis, Mich ...; Eiben, Gabriele; Lissner, Lauren, ...; Schwarz, Heike; Ahrens, Wolfgang; De Henauw, Stefa ...; Fraterman, Arno; Moreno, Luis A.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Pediatrics

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