What you see might not be what you get : Analysis of 15 prospective cases of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

• Introduction: Noninvasive follicular thyroid neoplasm with papillary-like nuclear (NIFTP) is a new entity. No previous study reported prospective cases, outlining using many quantitative and qualitative variables. Methods: Retrospective analysis of all (15) prospective NIFTP cases diagnosed between 2017 and 2021 at our institution. Statistical quantitative analysis outlined demographic, history, ultrasound, histopathology and treatment characteristics. Qualitative analysis examined the cases, with details provided on three cases to highlight the different possible presentations and configurations. Results: Mean age was 41.5 ± 9.91 years, 73.3% were females, and mean BMI was 29.49 ± 5.74 kg/m2. About 87% patients were symptomatic; 86.6% had neck swelling. Ultrasound (US) showed multiple nodules in 71.4% of cases. Fine-needle aspiration cytology (FNAC) showed that follicular lesion of undetermined significance (42.8%) was most common, followed by benign nodule (21.3%). Using the Bethesda System for Reporting Thyroid Cytopathology, 7 cases were category III, 3 category IV, 3 category II, and 1 category I. 60% of patients underwent total thyroidectomy. All cases were diagnosed postoperatively, 2 patients had additional papillary microcarcinoma. In 3 cases, the NIFTP site in the histopathology of resected specimen was different than the US-recommended site of the FNAC. Conclusion: We found discrepancies in the site and diagnosis of the preoperative US recommendation for the FNAC vs the postoperative histopathology of the specimen. These suggest that NIFTP might be incidentally and postoperatively diagnosed, irrespective of US or FNAC findings, hence its ‘true’ incidence might remain underestimated. As NIFTP cases higher BMI, Future research could predict preoperative diagnosis of NIFTP and explore associations with BMI. 

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)

Nyckelord

Follicular thyroid neoplasm

NIFTP

Nodule

Noninvasive

Papillary thyroid carcinoma

Papillary-like nuclear features

vitamin D

adult

autoimmune thyroiditis

benign neoplasm

blood vessel calcification

case report

cervical lymphadenopathy

clinical article

cytology

cytopathology

demographics

demography

dysphagia

dyspnea

Egyptian

epilepsy

female

fine needle aspiration biopsy

histopathology

human

human tissue

hypertension

incidence

male

medical history

middle aged

migraine

neck pain

neck swelling

obesity

oncocytoma

papillary carcinoma

Qatari

quantitative analysis

rare disease

retrospective study

Short Survey

thyroid cyst

thyroid hyperplasia

thyroid lobe

thyroid nodule

thyroid tumor

thyroidectomy

toxic goiter

ultrasound

Research on Citizen Centered Health, University of Skövde (Reacch US)

Medborgarcentrerad hälsa (Mech)

Publikations- och innehållstyp

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