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Transgenerational t...
Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome
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- Risal, Sanjiv (author)
- Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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- Li, Congru (author)
- Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden ; Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
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- Luo, Qing (author)
- Karolinska Institutet
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- Fornes, Romina (author)
- Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden ; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
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- Lu, Haojiang (author)
- Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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- Eriksson, Gustaw (author)
- Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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- Manti, Maria (author)
- Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Lindgren, Eva (author)
- Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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- Crisosto, Nicolas (author)
- Endocrinology and Metabolism Laboratory, West Division, School of Medicine, University of Chile, Santiago, Chile ; Endocrinology Unit, Department of Medicine, Clínica Alemana de Santiago, Faculty of Medicine, Clinica Alemana, Universidad del Desarrollo, Santiago, Chile
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- Maliqueo, Manuel (author)
- Endocrinology and Metabolism Laboratory, West Division, School of Medicine, University of Chile, Santiago, Chile
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- Echiburú, Barbara (author)
- Endocrinology and Metabolism Laboratory, West Division, School of Medicine, University of Chile, Chile
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- Recabarren, Sergio (author)
- Laboratory of Animal Physiology and Endocrinology, Faculty of Veterinary Sciences, University of Concepción, Chillán, Chile
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- Petermann, Teresa Sir (author)
- Endocrinology and Metabolism Laboratory, West Division, School of Medicine, University of Chile, Chile
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- Benrick, Anna, 1979- (author)
- Gothenburg University,Göteborgs universitet,Högskolan i Skövde,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden,Translationell medicin TRIM, Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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- Brusselaers, Nele (author)
- Karolinska Institutet
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- Qiao, Jie (author)
- Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
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- Deng, Qiaolin (author)
- Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden ; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
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- Stener-Victorin, Elisabet (author)
- Karolinska Institutet
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(creator_code:org_t)
- Cell Press, 2023
- 2023
- English.
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In: Cell Reports Medicine. - : Cell Press. - 2666-3791. ; 4:5
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Abstract
Subject headings
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- The transgenerational maternal effects of polycystic ovary syndrome (PCOS) in female progeny are being revealed. As there is evidence that a male equivalent of PCOS may exists, we ask whether sons born to mothers with PCOS (PCOS-sons) transmit reproductive and metabolic phenotypes to their male progeny. Here, in a register-based cohort and a clinical case-control study, we find that PCOS-sons are more often obese and dyslipidemic. Our prenatal androgenized PCOS-like mouse model with or without diet-induced obesity confirmed that reproductive and metabolic dysfunctions in first-generation (F1) male offspring are passed down to F3. Sequencing of F1–F3 sperm reveals distinct differentially expressed (DE) small non-coding RNAs (sncRNAs) across generations in each lineage. Notably, common targets between transgenerational DEsncRNAs in mouse sperm and in PCOS-sons serum indicate similar effects of maternal hyperandrogenism, strengthening the translational relevance and highlighting a previously underappreciated risk of transmission of reproductive and metabolic dysfunction via the male germline.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- adipose tissue
- male offspring
- male offspring to male germline
- maternal hyperandrogenism
- maternal obesity
- polycystic ovary syndrome
- small non-coding RNAs
- sperm
- transgenerational transmission
- Animals
- Case-Control Studies
- Female
- Humans
- Male
- Mice
- Obesity
- Pregnancy
- Reproduction
- Semen
- small untranslated RNA
- animal experiment
- animal model
- animal tissue
- Article
- case control study
- childhood obesity
- cohort analysis
- controlled study
- differential gene expression
- dyslipidemia
- fetus outcome
- fetus risk
- gene locus
- genetic risk
- genital system disease
- germ line
- high risk infant
- high risk patient
- human
- hyperandrogenism
- maternal fetal transmission
- metabolic disorder
- mouse
- nonhuman
- ovary polycystic disease
- prenatal exposure
- progeny
- risk assessment
- RNA analysis
- vertical transmission
- animal
- genetics
- Translationell medicin TRIM
- Translational Medicine TRIM
- prenatal androgen exposure
- women
- inheritance
- brothers
- disease
- sons
- susceptibility
- micrornas
- genetics
- pathway
- Cell Biology
- Research & Experimental Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Risal, Sanjiv
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Li, Congru
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Luo, Qing
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Fornes, Romina
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Lu, Haojiang
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Eriksson, Gustaw
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Manti, Maria
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Ohlsson, Claes, ...
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Lindgren, Eva
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Crisosto, Nicola ...
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Maliqueo, Manuel
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Echiburú, Barbar ...
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Recabarren, Serg ...
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Petermann, Teres ...
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Benrick, Anna, 1 ...
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Brusselaers, Nel ...
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Qiao, Jie
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Deng, Qiaolin
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Stener-Victorin, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Cell Reports Med ...
- By the university
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University of Skövde
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Karolinska Institutet
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University of Gothenburg