Sökning: id:"swepub:oai:DiVA.org:his-8783" >
Assessing chronic p...
Assessing chronic pelvic pain syndrome patients : Blood plasma factors and cortisol saliva
-
- Lundh, Dan (författare)
- Högskolan i Skövde,Institutionen för vård och natur,Forskningscentrum för Systembiologi,Fysiologi, farmakologi och toxikologi (P2T),Högskolan i Skövde, Institutionen för vård och natur
-
- Hedelin, Hans (författare)
- Department of Research and Development, Skaraborgs Sjukhus, Skövde, Sweden
-
- Jonsson, Karin (författare)
- Research and Development Centre, Department of Urology, Kärnsjukhuset, Skövde, Sweden
-
visa fler...
-
- Gifford, Mervyn (författare)
- Högskolan i Skövde,Institutionen för vård och natur,Folkhälsa,Högskolan i Skövde, Institutionen för vård och natur
-
- Larsson, Dennis (författare)
- Högskolan i Skövde,Institutionen för vård och natur,Forskningscentrum för Systembiologi,Fysiologi, farmakologi och toxikologi (P2T),Högskolan i Skövde, Institutionen för vård och natur
-
visa färre...
-
(creator_code:org_t)
- 2013-02-11
- 2013
- Engelska.
-
Ingår i: Scandinavian Journal of Urology. - : Informa Healthcare. - 2168-1813 .- 2168-1805. ; 47:6, s. 521-528
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.3...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective. The aim of this study was to identify changes in inflammatory molecules in the blood (plasma) of patients with chronic prostatitis/chronic pelvic syndrome (CP/CPPS) compared with controls. Altered levels indicate a systemic component by possible involvement of the prostate and/or the inner pelvic floor musculature. Material and methods. In 32 patients with CP/CPPS and 37 controls, blood plasma levels of testosterone, macrophage migration inhibitory factor (MIF), tumour necrosis factor-alpha (TNF-alpha), TNF-beta, interleukin-2 (IL-2) and IL-1 beta were measured by enzyme-linked immunosorbent assay. Cortisol in saliva samples was measured in the morning and late evening. All participants answered a questionnaire regarding their health profile. Results. Significantly higher levels of MIF (p = 0.012) were detected in patients. The testosterone level was, contrary to other studies, little lower in patients (p = 0.014; age adjusted). When controls with health issues and patients with a parallel disease were excluded, the MIF and TNF-alpha levels were higher in the patients (p = 0.007, p = 0.016, respectively) than in controls, and the testosterone was slightly lower in patients (p = 0.047). Conclusions. The findings show an immune response extending to the circulatory system, in which MIF makes a significant contribution to CP/CPPS. This study also indicates TNF-alpha as a circulatory component when excluding subjects with concomitant diseases. Both MIF and TNF-alpha have previously been highlighted for other diseases related to chronic pain and here also for CP/CPPS. These results provide further insights into the immunological basis of CP/CPPS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Medical sciences
- Medicin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas