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Detection of Cytome...
Detection of Cytomegalovirus DNA in Colorectal Tissue from Swedish and Vietnamese Patients with Colorectal Cancer
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- Dimberg, Jan (författare)
- Jönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. Biomedicinsk plattform
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- Thai, Trinh Hong (författare)
- Key Laboratory of Enzyme and Protein Technology, College of Science, Vietnam National University, Hanoi, Vietnam
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- Skarstedt, Marita (författare)
- Department of Clinical Microbiology, Ryhov County Hospital, Jönköping, Sweden
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- Löfgren, Sture (författare)
- Department of Clinical Microbiology, Ryhov County Hospital, Jönköping, Sweden
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- Zar, Niklas (författare)
- Department of Surgery, Ryhov County Hospital, Jönköping, Sweden
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- Matussek, Andreas (författare)
- Department of Laboratory Medicine, Ryhov County Hospital, Jönköping, Sweden
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(creator_code:org_t)
- 2013
- 2013
- Engelska.
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Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 33:11, s. 4947-4950
- Relaterad länk:
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Human cytomegalovirus (HCMV) has been implicated as a factor, which might be associated with colorectal cancer (CRC) progression. Data from studies with HCMV-infected tumour cell lines have highlighted an oncomodulatory potential of HCMV. In the present study, we aimed to evaluate the prevalence of HCMV DNA in CRC tissue compared to matched normal tissue, and its association with clinical factors.Patients and Methods: We used quantitative real-time polymerase chain reaction assay to detect HCMV DNA in 202 cancerous and paired normal tissue from Swedish (n=119) and Vietnamese (n=83) CRC patients.Results: Overall, the HCMV DNA rate was significantly higher in cancerous in relation to paired normal tissue. Furthermore, a significantly higher frequency (39.8%) of HCMV DNA was observed in cancer tissues from the Vietnamese patients compared to the Swedish patients (15.1%). The prevalence of HCMV DNA in CRC tissue of 50% of those with disseminated disease tended to be higher compared to those with localized disease, with a prevalence of 33.3% in Vietnamese patients.Conclusion: Our observations indicate that the prevalence of HCMV DNA differs significantly between cancer and matched normal tissues. Thus, these data support a possible role of CMV in CRC. Moreover, we noted differences between Swedish and Vietnamese patients, indicating a role of ethnicity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Colorectal cancer
- cytomegalovirus
- viral DNA
- Vietnamese
- Swedish
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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