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Independent skewing...
Independent skewing of the T cell and NK cell compartments associated with cytomegalovirus infection suggests division of labor between innate and adaptive immunity.
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- Bengnér, Malin (författare)
- Department of Infectious Diseases, Ryhov County Hospital, Jönköping, Sweden
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- Béziat, Vivien (författare)
- Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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- Ernerudh, Jan (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin
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- Nilsson, Bengt-Olof (författare)
- Department of Infectious Diseases, Ryhov County Hospital, Jönköping, Sweden
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- Löfgren, Sture (författare)
- Department of Laboratory Medicine, Clinical Microbiology, Ryhov County Hospital, Jönköping, Sweden
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- Wikby, Anders (författare)
- Jönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,Jonköping University, Sweden
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- Malmberg, Karl Johan (författare)
- Karolinska Institutet,Karolinska Institute, Sweden Oslo University Hospital, Norway University of Oslo, Norway
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- Strindhall, Jan (författare)
- Jönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. Biomedicinsk plattform,Jonköping University, Sweden
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(creator_code:org_t)
- 2013-09-25
- 2014
- Engelska.
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Ingår i: Age (Omaha). - : Springer Science and Business Media LLC. - 0161-9152 .- 1574-4647. ; 36:2, s. 571-582
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Cytomegalovirus (CMV) infection induces profound changes in different subsets of the cellular immune system. We have previously identified an immune risk profile (IRP) where CMV-associated changes in the T cell compartment, defined as a CD4/CD8 ratio < 1, are associated with increased mortality in elderly people. Since natural killer (NK) cells have an important role in the defense against viral infections, we examined whether the expansion of CD8 + T cells seen in individuals with CD4/CD8 ratio < 1 is coupled to a parallel skewing of the NK cell compartment. A number of 151 subjects were examined with CMV serology and a flow cytometry panel for assessment of T cell and NK cell subsets. CMV-seropositive individuals had higher frequencies of CD57 + and NKG2C + NK cells and lower frequencies of NKG2A + NK cells, in line with a more differentiated NK cell compartment. Intriguingly, however, there was no correlation between CD4/CD8 ratio and NK cell repertoires among CMV-seropositive donors, despite the profound skewing of the T cell compartment in the group with CD4/CD8 ratio < 1. Conversely, donors with profound expansion of NK cells, defined as NKG2C + NK cells with high expression of CD57 and ILT-2, did not display more common changes in their T cell repertoire, suggesting that NK cell expansion is independent of the T cell-defined IRP. Altogether, these results indicate that the effect of CMV on CD8 T cells and NK cells is largely nonoverlapping and independent.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Nyckelord
- Cytomegalovirus
- Immunosenescence
- Immune risk profile
- Natural killer cells
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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