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Perforin, CD28 and ...
Perforin, CD28 and CD95 expression in circulating CD4 and CD8 cells as predictors of head and neck (H&N) cancer patient survival
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- Laytragoon-Lewin, Nongnit (författare)
- Department of Laboratory Medicine, Ryhov Hospital, SE-55185, Jönköping, Sweden
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- Jonson, Fredrik (författare)
- Department of ENT, Ryhov Hospital, Jönköping, Sweden
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- Lundgren, Jan (författare)
- Department of ENT, Karolinska University Hospital, Stockholm, Sweden
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- Rutqvist, Lars Erik (författare)
- Swedish Match AB, Stockholm, Sweden
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- Wikby, Anders (författare)
- Jönköping University,HHJ. Åldrande - livsvillkor och hälsa
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- Löfgren, Sture (författare)
- Department of Laboratory Medicine, Ryhov Hospital, SE-55185, Jönköping, Sweden
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- Lewin, Freddi (författare)
- Department of Oncology, Ryhov Hospital, Jönköping, Sweden
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(creator_code:org_t)
- 2014-10-25
- 2014
- Engelska.
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Ingår i: Medical Oncology. - : Springer Science and Business Media LLC. - 1357-0560 .- 1559-131X. ; 31:12, s. 290-
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Long-term survival of H&N cancer patients has not improved significantly over the last 30 years. The possibility of using circulating blood cell phenotypes as a prognostic biomarker of H&N cancer patient was investigated in this study. Pre-treatment, circulating T lymphocyte subpopulations as well as the survival time of the patients in question were studied. Upregulated CD4+ perforin+ and CD8+ CD95+ but downregulated CD4+ CD28+ (p < 0.001) were detected in H&N cancer patients. With 3 years of follow-up time, an increase in the frequency of the pre-treatment, circulating CD4+ perforin+ cells and CD8+ perforin+ cells was showed to have reverse effects on the survival time in H&N cancer patients (p < 0.01). Detection of perforin? frequency in CD4+ and CD8+ lymphocyte by FACS is fast, simple and cost-effective. A potential role of perforin expression in CD4+ and CD8+ cells as a prognostic biomarker for H&N cancer patient in the clinical setting was suggested.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Perforin
- CD28
- CD95
- Circulating T cells
- Survival time H&N cancer patients
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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