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Frailty index as a ...
Frailty index as a predictor of all-cause and cause-specific mortality in a Swedish population-based cohort
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Jiang, M. (författare)
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Foebel, A. D. (författare)
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- Kuja-Halkola, R. (författare)
- Karolinska Institutet
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- Karlsson, Ida K. (författare)
- Karolinska Institutet,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Pedersen, N. L. (författare)
- Karolinska Institutet
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- Hägg, S. (författare)
- Karolinska Institutet
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- Jylhävä, J. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2017-12-19
- 2017
- Engelska.
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Ingår i: Aging. - : Impact Journals LLC. - 1945-4589. ; 9:12, s. 2629-2646
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Frailty is a complex manifestation of aging and associated with increased risk of mortality and poor health outcomes. However, younger individuals (under 65 years) are less-studied in this respect. Also, the relationship between frailty and cause-specific mortality in community settings is understudied. We used a 42-item Rockwood-based frailty index (FI) in the Swedish Adoption/Twin Study of Aging (n=1477; 623 men, 854 women; aged 29-95 years) and analyzed its association with all-cause and cause-specific mortality in up to 30-years of follow-up. Deaths due to cardiovascular disease (CVD), cancer, dementia and other causes were considered as competing risks. The FI was independently associated with increased risk for all-cause mortality in younger (< 65 years; HR per increase in one deficit 1.11, 95%CI 1.07-1.17) and older (≥65 years; HR 1.07, 95%CI 1.04-1.10) women and in younger men (HR 1.05, 95%CI 1.01-1.10). In cause-specific mortality analysis, the FI was strongly predictive of CVD mortality in women (HR per increase in one deficit 1.13, 95%CI 1.09-1.17), whereas in men the risk was restricted to deaths from other causes (HR 1.07, 95%CI 1.01-1.13). In conclusion, the FI is a strong mortality predictor especially among younger individuals and its associations with cause-specific mortality are sex-specific.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Cancer mortality
- Cardiovascular disease mortality
- Competing risks
- Early risk marker
- Frailty
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Aging
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