SwePub
Sök i LIBRIS databas

  Utökad sökning

id:"swepub:oai:DiVA.org:hj-47078"
 

Sökning: id:"swepub:oai:DiVA.org:hj-47078" > Association between...

Association between copy number variation and response to social skills training in Autism Spectrum Disorder

Tammimies, Kristiina (författare)
Karolinska Institutet
Li, Danyang (författare)
Karolinska Institutet
Rabkina, Ielyzaveta (författare)
Center of Neurodevelopmental Disorders (KIND), Division of Neuropsychiatry, Centre for Psychiatry Research, Department of Women’s and Children’s Health, Karolinska Institutet, Solna, Sweden,Karolinska Inst, Dept Womens & Childrens Hlth, Ctr Psychiat Res, Ctr Neurodev Disorders KIND,Div Neuropsychiat, Solna, Sweden
visa fler...
Stamouli, Sofia (författare)
Karolinska Institutet
Becker, Martin (författare)
Karolinska Institutet
Nicolaou, Veronika (författare)
Center of Neurodevelopmental Disorders (KIND), Division of Neuropsychiatry, Centre for Psychiatry Research, Department of Women’s and Children’s Health, Karolinska Institutet, Solna, Sweden,Karolinska Inst, Dept Womens & Childrens Hlth, Ctr Psychiat Res, Ctr Neurodev Disorders KIND,Div Neuropsychiat, Solna, Sweden
Berggren, Steve (författare)
Center of Neurodevelopmental Disorders (KIND), Division of Neuropsychiatry, Centre for Psychiatry Research, Department of Women’s and Children’s Health, Karolinska Institutet, Solna, Sweden,Karolinska Inst, Dept Womens & Childrens Hlth, Ctr Psychiat Res, Ctr Neurodev Disorders KIND,Div Neuropsychiat, Solna, Sweden;Stockholm Hlth Serv, Child & Adolescent Psychiat, Stockholm, Sweden
Coco, Christina (författare)
Karolinska Institutet
Falkmer, Torbjörn, 1958- (författare)
Linköpings universitet,Jönköping University,HHJ. CHILD,Curtin Univ, Sch Occupat Therapy Social Work & Speech Pathol, Curtin Autism Res Grp, Bentley, WA, Australia;Linkoping Univ, Dept Med & Hlth Sci, Pain & Rehabil Ctr, Linkoping, Sweden,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
Jonsson, Ulf, 1974- (författare)
Karolinska Institutet,Uppsala universitet,Barn- och ungdomspsykiatri,Karolinska Inst, Dept Womens & Childrens Hlth, Ctr Psychiat Res, Ctr Neurodev Disorders KIND,Div Neuropsychiat, Solna, Sweden;Stockholm Hlth Serv, Child & Adolescent Psychiat, Stockholm, Sweden,Center of Neurodevelopmental Disorders (KIND), Division of Neuropsychiatry, Centre for Psychiatry Research, Department of Women’s and Children’s Health, Karolinska Institutet, Solna, Sweden,Karolinska Inst, Sweden; Stockholm Hlth Serv, Sweden; Uppsala Univ, Sweden
Choque-Olsson, Nora (författare)
Karolinska Institutet
Bölte, Sven (författare)
Center of Neurodevelopmental Disorders (KIND), Division of Neuropsychiatry, Centre for Psychiatry Research, Department of Women’s and Children’s Health, Karolinska Institutet, Solna, Sweden, and Curtin Autism Research Group, School of Occupational Therapy, Social Work and Speech Pathology, Curtin University, Bentley, Australia,Karolinska Inst, Dept Womens & Childrens Hlth, Ctr Psychiat Res, Ctr Neurodev Disorders KIND,Div Neuropsychiat, Solna, Sweden;Stockholm Hlth Serv, Child & Adolescent Psychiat, Stockholm, Sweden;Curtin Univ, Sch Occupat Therapy Social Work & Speech Pathol, Curtin Autism Res Grp, Bentley, WA, Australia
visa färre...
 (creator_code:org_t)
2019-07-08
2019
Engelska.
Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 9:1
Relaterad länk:
https://doi.org/10.1...
visa fler...
https://www.nature.c...
https://uu.diva-port... (primary) (Raw object)
https://liu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
https://urn.kb.se/re...
https://urn.kb.se/re...
http://kipublication...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Challenges in social communication and interaction are core features of autism spectrum disorder (ASD) for which social skills group training (SSGT) is a commonly used intervention. SSGT has shown modest and heterogeneous effects. One of the major genetic risk factors in ASD is rare copy number variation (CNV). However, limited information exists whether CNV profiles could be used to aid intervention decisions. Here, we analyzed the rare genic CNV carrier status for 207 children, of which 105 received SSGT and 102 standard care as part of a randomized clinical trial for SSGT. We found that being a carrier of rare genic CNV did not have an impact on the SSGT outcome measured by the parent-report Social Responsiveness Scale (SRS). However, when stratifying by pathogenicity and size of the CNVs, we identified that carriers of clinically significant and large genic CNVs (>500 kb) showed inferior SRS outcomes at post-intervention (P = 0.047 and P = 0.036, respectively) and follow-up (P = 0.008 and P = 0.072, respectively) when adjusting for standard care effects. Our study provides preliminary evidence that carriers of clinically significant and large genic CNVs might not benefit as much from SSGT as non-carriers. Our results indicate that genetic information might help guide the modifications of interventions in ASD. 

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Arbetsterapi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Occupational Therapy (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Annan medicin och hälsovetenskap -- Övrig annan medicin och hälsovetenskap (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Other Medical and Health Sciences -- Other Medical and Health Sciences not elsewhere specified (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy