Periodontal treatment influences risk markers for atherosclerosis in patients with severe periodontitis

• This study investigated the effect of mechanical infection control for periodontitis and periodontal surgery on the prevalence of well-established risk factors for atherosclerosis, and plasma levels of cytokines, antibodies against heat shock proteins and markers of systemic inflammation. Sixty-eight patients between 39 and 73 years of age with severe periodontitis who had been referred to four specialist periodontology clinics in Sweden were investigated. A fasting venous blood sample was taken at baseline and additional samples were collected after 3 and 12 months. A total of 54 patients underwent periodontal treatment. The periodontal treatment was successful, as pathogenic gingival pockets decreased significantly. Plasma glucose, lipids and markers of systemic inflammation were not significantly altered after 3 months. One year after the initial treatment, HDL-C concentrations were significantly increased (Δ0.08 mmol/L) whereas LDL-C concentrations decreased (Δ0.23 mmol/L). Haptoglobin concentrations were also lower. Interleukin-18 and interferon-γ levels were also lower after 12 months (60 ng/L (-23%) and 11 ng/L (-97%) respectively). Treatment had no effect on plasma levels of IgA, IgG1, IgG2 antibodies against heat shock proteins. In conclusion, this study indicates that standard treatment for periodontal disease induces systemic changes in several biochemical markers that reflect the risk for atherosclerosis. 

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Nyckelord

Atherosclerosis

Inflammation

Longitudinal study

Periodontitis

Risk factors

Treatment

biochemical marker

cytokine

gamma interferon

glucose

haptoglobin

heat shock protein

high density lipoprotein cholesterol

immunoglobulin A antibody

immunoglobulin antibody

immunoglobulin G1 antibody

immunoglobulin g2 antibody

interleukin 18

lipid

low density lipoprotein cholesterol

protein antibody

unclassified drug

adult

aged

article

blood sampling

cardiovascular risk

controlled study

female

glucose blood level

human

infection control

lipid blood level

major clinical study

male

mouth hygiene

periodontics

priority journal

protein blood level

risk factor

risk reduction

Sweden

tooth extraction

venous blood

Biological Markers

Cholesterol

HDL

Cholesterol

LDL

Cytokines

Humans

Interferon-gamma

Interleukin-18

Lipids

Middle Aged

Smoking

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)