Bone response to free form-fabricated hydroxyapatite and zirconia scaffolds : A histological study in the human maxilla

• Objectives: Synthetic and biological materials are increasingly used to provide temporary or permanent scaffolds for bone regeneration. This study evaluated the effect of material chemistry and microporosity on bone ingrowth and osseointegration of zirconia (ZrO2) and hydroxyapatite (HA) scaffolds in the human maxilla.Material and methods: Twelve patients subjected to dental implant placement were enrolled in the study. Scaffolds of ZrO 2 and HA were placed in the maxilla of each subject, using a randomization protocol. After 3 months of healing, biopsies were harvested comprising the scaffolds and surrounding bone tissue. The biopsies were processed for histological evaluation and morphometric analysis (bone ingrowth and bone-to-scaffold contact).Results: Healing was uneventful in all cases. All scaffolds demonstrated a measurable bone response using light microscopy and scanning electron microscopy. Microporous HA scaffolds revealed four times larger bone ingrowth and seven times larger bone contact as compared with ZrO2 scaffolds.Conclusion: The results show that chemistry and microporosity of HA promote bone ingrowth and bone contact of ceramic scaffolds in human maxilla.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Biomaterials Science (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Bone regeneration

Free form fabrication

Human

Hydroxyapatite

Implant

Microporosity

Scaffolds

Zirconia

biomaterial

tissue scaffold

zirconium

zirconium oxide

adult

aged

article

bone prosthesis

chemistry

clinical trial

computer aided design

controlled clinical trial

controlled study

drug effect

jaw

maxilla

methodology

middle aged

nonparametric test

physiology

porosity

randomized controlled trial

tissue regeneration

tooth implantation

ultrastructure

Alveolar Process

Biocompatible Materials

Bone Substitutes

Computer-Aided Design

Dental Implantation

Endosseous

Dental Implants

Guided Tissue Regeneration

Humans

Hydroxyapatites

Osseointegration

Statistics

Nonparametric

Tissue Scaffolds

Young Adult

Adult

Aged

Alveolar Process

drug effects

physiology

surgery

ultrastructure

Biocompatible Materials

chemistry

therapeutic use

Bone Regeneration

Bone Substitutes

Computer-Aided Design

Dental Implantation

Endosseous

methods

Dental Implants

Guided Tissue Regeneration

Humans

Hydroxyapatites

Maxilla

Middle Aged

Osseointegration

Porosity

Statistics

Nonparametric

Tissue Scaffolds

Young Adult

Zirconium

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)