Sökning: id:"swepub:oai:DiVA.org:hkr-15864" >
Prospective evaluat...
Prospective evaluation of glutamine and phospholipids levels in first degree relatives of patients with Type 1 Diabetes from a multiethnic population
-
- Araujo de Pina Cabral, DB (författare)
- Brasilien
-
- Dantas, JR (författare)
- Brasilien
-
- Skärstrand, H (författare)
- Lund University
-
visa fler...
-
- Barone, B (författare)
- Brasilien
-
- Carvalho, F (författare)
- Brasilien
-
- Tortora, R (författare)
- Brasilien
-
- Milech, A (författare)
- Brasilien
-
- Vaziri-Sani, Fariba (författare)
- Lunds universitet
-
- Oliveira, JE (författare)
- Brasilien
-
- Zajdenverg, L (författare)
- Brasilien
-
- Rodacki, M (författare)
- Brasilien
-
- Vaziri Sani, Fariba (författare)
- Lund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups
-
Oliveira, J E P (författare)
-
Araujo de Pina Cabral, D B (författare)
-
Dantas, J R (författare)
-
- Skärstrand, Hanna (författare)
- Lund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups
-
visa färre...
-
(creator_code:org_t)
- BioMed Central (BMC), 2015
- 2015
- Engelska.
-
Ingår i: Diabetology and Metabolic Syndrome. - : BioMed Central (BMC). - 1758-5996 .- 1758-5996. ; 7:52
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://dmsjournal.b...
-
https://portal.resea... (primary) (free)
-
http://www.ncbi.nlm.... (free)
-
http://dx.doi.org/10... (free)
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: A dysregulation in the metabolism of lipids may be an early marker of autoimmunity in Type 1 Diabetes (T1D). It would be of general importance to identify metabolic patterns that would predict the risk for T1D later in life. The aim of this study was to perform a prospective evaluation of glutamine and phospholipids levels in Brazilian first degree relatives (FDR) of patients with T1D in a mean interval of 5 years.FINDINGS: Brazilian FDR (n = 30) of patients with T1D were evaluated and blood was sampled to measure the levels of glutamine and phospholipids in the fasting serum by quantitative colorimetric method. The tests were repeated after a mean interval of 5 years and compared to a control group (n = 20). The FDR presented lower levels of phospholipids than controls (p = 0.028), but not of glutamine (p = 0.075). Phospholipids levels decreased over time (p = 0.028) in FDR and were associated with Glutamic acid decarboxylase autoantibody (GADA) titers (p = 0.045), autoantibody positivity (p = 0.008) and PTPN22 polymorphisms (p = 0.014).CONCLUSIONS: In this Brazilian multiethnic population, there was a significant decrease in phospholipids levels in FDR in patients with T1D during a 5-year prospective follow-up, as well as a significant association between these metabolite, GADA and PTPN22 polymorphisms. For Glutamine no difference was found. These findings suggest that a dysregulation in the metabolism of lipids may precede the onset of the autoimmunity in T1D.
Ämnesord
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Metabolic
- Diabetes
- Non-whites
- Antibodies
- Multiethnic
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
- Av författaren/redakt...
-
Araujo de Pina C ...
-
Dantas, JR
-
Skärstrand, H
-
Barone, B
-
Carvalho, F
-
Tortora, R
-
visa fler...
-
Milech, A
-
Vaziri-Sani, Far ...
-
Oliveira, JE
-
Zajdenverg, L
-
Rodacki, M
-
Oliveira, J E P
-
Araujo de Pina C ...
-
Dantas, J R
-
Skärstrand, Hann ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Diabetology and ...
- Av lärosätet
-
Högskolan Kristianstad
-
Lunds universitet