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Removing Critical G...
Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals-The ATHENA Project
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- Kortenkamp, Andreas (författare)
- Brunel University, GBR,Institute of Environment, Health and Societies, Brunel University London, UK
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- Axelstad, Marta (författare)
- DTU Technical University of Denmark, Denmark,National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark
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- Baig, Asma H. (författare)
- Brunel University, GBR,Institute of Environment, Health and Societies, Brunel University London, UK
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- Bergman, Åke, 1950- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Örebro University, Sweden
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- Bornehag, Carl-Gustav, 1957- (författare)
- Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Department of Health Sciences, Karlstad University, Karlstad, Sweden
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- Cenijn, Peter (författare)
- Vrije University, NLD,Department of Environment and Health, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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- Christiansen, Sofie (författare)
- National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark,DTU Technical University of Denmark, Denmark
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- Demeneix, Barbara (författare)
- CNRS, FRA,Unité PhyMA Laboratory, Adaptation du Vivant, Muséum national d'Histoire naturelle, Centre National de la Recherche Scientifique, Paris, France
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- Derakhshan, Arash (författare)
- Erasmus MC, Academy, NLD,Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Centre, Rotterdam, The Netherlands
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- Fini, Jean-Baptiste (författare)
- Charité – Universitätsmedizin Berlin, DEU,Unité PhyMA Laboratory, Adaptation du Vivant, Muséum national d'Histoire naturelle, Centre National de la Recherche Scientifique, Paris, France
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- Fraedrich, Caroline (författare)
- Charité – Universitätsmedizin Berlin, DEU,Department of Experimental Endocrinology, Charitė - Universitätsmedizin Berlin, Berlin, Germany
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- Hamers, Timo (författare)
- Department of Environment and Health, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
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- Hellwig, Lina (författare)
- Dept. of Experimental Neurology, Dept. of Neurology, Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany; Charité-BIH Centrum Therapy and Research, BIH Stem Cell Core Facility, Charité - Universitätsmedizin Berlin, Berlin, Germany
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- Koehrle, Josef (författare)
- Department of Experimental Endocrinology, Charitė - Universitätsmedizin Berlin, Berlin, Germany
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- Korevaar, Tim I. M. (författare)
- Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Centre, Rotterdam, The Netherlands
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- Lindberg, Johan (författare)
- RISE,Kemiska processer och läkemedel
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- Martin, Olwenn (författare)
- Brunel University, GBR,Institute of Environment, Health and Societies, Brunel University London, UK
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- Meima, Marcel E. (författare)
- Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Centre, Rotterdam, The Netherlands
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- Mergenthaler, Philipp (författare)
- Dept. of Experimental Neurology, Dept. of Neurology, Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health, Berlin, Germany
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- Nikolov, Nikolai (författare)
- DTU Technical University of Denmark, Denmark,National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark
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- Du Pasquier, David (författare)
- Lab Watchfrog, FRA,Laboratoire Watchfrog, Evry, France
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- Peeters, Robin P. (författare)
- Erasmus MC, NLD,Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Centre, Rotterdam, The Netherlands
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- Platzack, Bjorn (författare)
- RISE,Kemiska processer och läkemedel
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- Ramhoj, Louise (författare)
- National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark,DTU Technical University of Denmark, Denmark
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- Remaud, Sylvie (författare)
- Unité PhyMA Laboratory, Adaptation du Vivant, Muséum national d'Histoire naturelle, Centre National de la Recherche Scientifique CNRS 7, Paris, France
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- Renko, Kostja (författare)
- Charité – Universitätsmedizin Berlin, DEU,Department of Experimental Endocrinology, Charitė - Universitätsmedizin Berlin, Berlin, Germany
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- Scholze, Martin (författare)
- Brunel University, GBR,Institute of Environment, Health and Societies, Brunel University London, UK
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- Stachelscheid, Harald (författare)
- Charité-BIH Centrum Therapy and Research, BIH Stem Cell Core Facility, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health, Berlin, Germany
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- Svingen, Terje (författare)
- National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark,DTU Technical University of Denmark, Denmark
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- Wagenaars, Fabian (författare)
- Department of Environment and Health, Vrije Universiteit Amsterdam, VUA, Amsterdam, The Netherlands
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- Wedebye, Eva Bay (författare)
- National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark,DTU Technical University of Denmark, Denmark
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- Zoeller, R. Thomas, 1952- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Orebro University, Sweden
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(creator_code:org_t)
- 2020-04-28
- 2020
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 21:9
- Relaterad länk:
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https://doi.org/10.3...
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https://kau.diva-por... (primary) (Raw object)
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https://www.mdpi.com...
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https://ri.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The test methods that currently exist for the identification of thyroid hormone system-disrupting chemicals are woefully inadequate. There are currently no internationally validated in vitro assays, and test methods that can capture the consequences of diminished or enhanced thyroid hormone action on the developing brain are missing entirely. These gaps put the public at risk and risk assessors in a difficult position. Decisions about the status of chemicals as thyroid hormone system disruptors currently are based on inadequate toxicity data. The ATHENA project (Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies) has been conceived to address these gaps. The project will develop new test methods for the disruption of thyroid hormone transport across biological barriers such as the blood-brain and blood-placenta barriers. It will also devise methods for the disruption of the downstream effects on the brain. ATHENA will deliver a testing strategy based on those elements of the thyroid hormone system that, when disrupted, could have the greatest impact on diminished or enhanced thyroid hormone action and therefore should be targeted through effective testing. To further enhance the impact of the ATHENA test method developments, the project will develop concepts for better international collaboration and development in the area of thyroid hormone system disruptor identification and regulation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
Nyckelord
- endocrine disruptors
- thyroid hormone system
- brain development
- test method development
- test method validation
- risk assessment
- Biology
- Biologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Kortenkamp, Andr ...
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Axelstad, Marta
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Baig, Asma H.
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Bergman, Åke, 19 ...
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Bornehag, Carl-G ...
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Cenijn, Peter
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visa fler...
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Christiansen, So ...
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Demeneix, Barbar ...
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Derakhshan, Aras ...
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Fini, Jean-Bapti ...
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Fraedrich, Carol ...
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Hamers, Timo
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Hellwig, Lina
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Koehrle, Josef
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Korevaar, Tim I. ...
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Lindberg, Johan
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Martin, Olwenn
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Meima, Marcel E.
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Mergenthaler, Ph ...
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Nikolov, Nikolai
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Du Pasquier, Dav ...
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Peeters, Robin P ...
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Platzack, Bjorn
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Ramhoj, Louise
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Remaud, Sylvie
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Renko, Kostja
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Scholze, Martin
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Stachelscheid, H ...
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Svingen, Terje
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Wagenaars, Fabia ...
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Wedebye, Eva Bay
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Zoeller, R. Thom ...
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International Jo ...
- Av lärosätet
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Karlstads universitet
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Örebro universitet
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RISE