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Prenatal exposure t...
Prenatal exposure to bisphenols and cognitive function in children at 7 years of age in the Swedish SELMA study
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- Bornehag, Carl-Gustav, 1957- (författare)
- Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Karlstad University, Karlstad, Sweden; Icahn School of Medicine at Mount Sinai, New York City, USA
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- Engdahl, Elin (författare)
- Uppsala universitet,Uppsala University,Miljötoxikologi
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- Unenge Hallerbäck, Maria (författare)
- Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Karlstad University, Karlstad, Sweden
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- Wikström, Sverre, 1978- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Örebro University, Örebro, Sweden
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- Lindh, Christian (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Lund University, Lund, Sweden
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- Rüegg, Joëlle (författare)
- Uppsala universitet,Uppsala University,Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Karlstad University, Karlstad, Sweden; Uppsala University, Uppsala, Sweden,Miljötoxikologi
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- Tanner, Eva (författare)
- Icahn School of Medicine at Mount Sinai, New York City, USA
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- Gennings, Chris (författare)
- Icahn School of Medicine at Mount Sinai, New York City, USA
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 150
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Abstract
Ämnesord
Stäng
- Background: Experimental evidence demonstrates that exposure to bisphenol A (BPA), and the recently intro-duced alternatives bisphenol S (BPS) and bisphenol F (BPF) alter normal neurodevelopment. More research is needed to evaluate the associations between exposure to individual BPA alternatives and neurodevelopmental outcomes in humans. Objective: The present study aimed at examining the individual associations between prenatal BPA , BPS and BPF exposure and cognitive outcomes in children at age 7 years. Method: Women were enrolled in the Swedish Environmental Longitudinal Mother and Child, Asthma and Al-lergy (SELMA) study, at gestational median week 10.0, and their children were examined for cognitive function at 7 years of age (N = 803). Maternal urina r y BPA , BPS, and BPF concentrations were measured at enrollment and children?s cognitive function at the age of 7 years was measured using the Wechsler Intelligence Scale for Children IV (WISC-IV). Results: A l l three bisphenols were detected in over 90% of the women, where BPA had the highest geometric mean concentrations (1.55 ng/mL), followed by BPF (0.16 ng/mL) and BPS (0.07 ng/mL). Prenatal BPF exposure was associated with decreased f u l l scale IQ (13 =-1.96, 95%CI;-3.12;-0.80), as we l l as with a decrease in a l l four sub scales covering verbal comprehension, perceptual reasoning, working memor y and processing speed. This association corresponded to a 1.6-point lower IQ score for an inter-quartile-range (IQR) change in prenatal BPF exposure (IQR = 0.054 & ndash;0.350 ng/mL). In sex-stratified analyses, significant associations with f u l l scale IQ were found for boys (13 = - 2.86, 95%CI;-4.54;-1.18), while the associations for girls did not reach significance (13 =-1.38, 95%CI;-2.97; 0.22). No significant associations between BPA nor BPS and cognition were found. Discussion: Prenatal exposure to BPF was significantly associated with children?s cognitive function at 7 years. Since BPF is replacing BPA in numerous consumer products globally, this finding urgently ca l l for further studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Bisphenols
- BPA
- BPS
- BPF
- Cognitive function
- Prenatal exposu r e
- Public Health Science
- Folkhälsovetenskap
- Bisphenols
- BPA
- BPF
- BPS
- Cognitive function
- Prenatal exposure
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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