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Synthesis of cyclic...
Synthesis of cyclic polyamines by enzymatic generation of an amino aldehyde in situ
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- Engelmark Cassimjee, Karim (författare)
- KTH,Biokemi
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- Marín, Sílvia Rodríguez (författare)
- KTH,Biokemi
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- Berglund, Per (författare)
- KTH,Biokemi
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(creator_code:org_t)
- 2012-07-03
- 2012
- Engelska.
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Ingår i: Macromolecular rapid communications. - : Wiley. - 1022-1336 .- 1521-3927. ; 33:18, s. 1580-1583
- Relaterad länk:
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https://urn.kb.se/re...
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visa fler...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Multifunctional polycationic polyamines, for example, used in drug and gene delivery, have product range limitations in their synthesis methods. Here, we synthesize a polyamine by forming a self-assembling amino aldehyde from the corresponding amino alcohol with horse liver alcohol dehydrogenase (HLADH), followed by reduction. Circular polyamines were synthesized from 3-amino-propan-1-ol as starting material, analogous to cyclic polyamines formed from azetidin. The product had an isolated yield of 89.7% or 15.3 g L -1. The predicted range of possible polyamine products by this method is broad since many amino alcohols are putative substrates for HLADH. The enzyme also had activity for 2-amino-propan-1-ol and 2-amino-2-phenyl-ethanol, for which the enantioselectivity was 330 (S) and 32 (R), respectively.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- enzyme catalysis
- hydrophilic polymers
- polyamines
- polyelectrolytes
- self-assembly
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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