Direct STD NMR Identification of beta-Galactosidase Inhibitors from a Virtual Dynamic Hemithioacetal System

•  The formation of a dynamic hemithioacetal system and its application toward the discovery of ß-galactosidase inhibitors were successfully investigated. The designed dynamic system, which has a virtual character in neutral aqueous media, was subjected to a direct in situ identification of the best inhibitors by 1H STD NMR spectroscopy (ONPC : o-nitrophenyl-β-galactopyranoside).

Ämnesord

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

Nyckelord

beta-galactosidase

dynamic chemistry

hemithioacetals

inhibition

NMR spectroscopy

NUCLEAR-MAGNETIC-RESONANCE

COMBINATORIAL LIBRARIES

ESCHERICHIA-COLI

LIGAND-BINDING

LIVING CELLS

ACTIVE-SITE

CHEMISTRY

SPECTROSCOPY

RECEPTORS

PROTEIN

Chemistry

Kemi

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