Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution

• The anti-HIV nucleoside lamivudine was asymmetrically synthesized in only three steps via a novel surfactant-treated subtilisin Carlsberg-catalyzed dynamic kinetic resolution protocol. The enantiomer of lamivudine could also be accessed using the same protocol catalyzed by Candida antarctica lipase B.

Ämnesord

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

Nyckelord

Potent Antiviral Agent

Secondary Alcohols

Enantioselective Synthesis

Nucleoside Analogs

Organic-Synthesis

Anti-Hiv

Lipase

Replication

Catalysts

3tc(Tm)

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)