Bioaccessibility of FERRO-chromium and ferrosilicon-chromium particles compared to pure metals and stainless steel-Aspects of human exposure

• Product safety legislation requires that industry indentifies and demonstrates any human risks associated with the manufacture and use of products which are placed on the market throughout their entire life cycle. This process involves detailed assessment of potential hazards of the products/material related to health effect endpoints, and requires accurate generation and interpretation of data which can be used to determine essential characteristics of the material. Temporary or permanent adverse health effects depend either on the shape or physical characteristics of the particles, and/or on chemical interactions with the particle surface upon human exposure. Since alloys represent the most significant and widespread use of many engineering metals, it is important to develop a detailed understanding of the characteristics and behaviour of this group of materials with a minimum dependence on in-vivo testing. The aim of this presentation is to summarize generated bioaccessibility data for ferro-chromium and ferro-silicon-chromium alloys in particulate form when exposed to different synthetic biological media. The selection of test media aims to mimic relevant human exposures, as far as practical, with the focus on inhalation and subsequent ingestion of inhaled particles. The generation of bioaccessibility data combined with detailed particle and material characterization, also from a surface perspective, is essential for accurate risk assessment and understanding of potential adverse effects that may be caused by ferro-chromium and ferro-silicon-chromium alloys. For comparison, a similar approach has been conducted on particles of pure iron, pure chromium and stainless steel grade AISI 316L. Generated data is used within the framework of risk assessment on ferro-chromium and ferro-siliconchromium alloys conducted by the Finnish Institute of Occupational Health, Helsinki, Finland.

Ämnesord

NATURVETENSKAP  -- Kemi -- Annan kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Other Chemistry Topics (hsv//eng)

Nyckelord

Adverse effect

Adverse health effects

Bioaccessibility

Biological media

Chemical interactions

Essential characteristic

Finnish

Health effects

Helsinki

Finland

Human exposures

Human risks

In-vivo

Inhaled particles

Interpretation of data

Material characterizations

Occupational health

Particle surface

Physical characteristics

Potential hazards

Product safety

Pure iron

Pure metals

Stainless steel grades

Accident prevention

Chromium alloys

Health hazards

Industrial hygiene

Risk assessment

Silicon steel

Chromium

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