Gold colloid analysis by inductively coupled plasma-mass spectrometry in a single particle mode

• Analysis in a single particle mode of gold colloids in water has been performed by inductively coupled plasma-mass spectrometry (ICP-MS). The signal induced by the flash of ions due to the ionization of a colloid in the plasma torch can be measured for the ions (197)An(+) by the mass spectrometer without interferences. The intensity of the MS signal is recorded in time scan. The recorded peak distributions were analysed as a function of the colloid size for five monodisperse colloids (80-250 nm). This study describes the experimental conditions to analyse gold colloids in a single particle mode. The size detection limit is around 25 nm corresponding to 0.15 fg colloids and one particle per ml may be detected during a 1 min time scan within standard procedure.

Nyckelord

single particle analysis

inductively coupled plasma-mass spectrometry

ICP-MS

gold colloid

colloid size

scattering

biology

waters

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)