Sökning: id:"swepub:oai:DiVA.org:kth-154189" >
The protein express...
The protein expression of TRP-1 and galectin-1 in cutaneous malignant melanomas
-
- Bolander, Å. (författare)
- Uppsala universitet,Enheten för onkologi
-
- Agnarsdóttir, Margrét (författare)
- Uppsala universitet,Institutionen för genetik och patologi
-
- Strömberg, S. (författare)
- Uppsala universitet,Institutionen för genetik och patologi
-
visa fler...
-
- Pontén, Fredrik (författare)
- Uppsala universitet,Institutionen för genetik och patologi
-
- Hesselius, P. (författare)
- Uppsala universitet,Enheten för onkologi
-
- Uhlén, Mathias (författare)
- KTH,Proteomik
-
- Bergqvist, Michael (författare)
- Uppsala universitet,Enheten för onkologi,Bergqvist, Michael
-
visa färre...
-
(creator_code:org_t)
- 2008
- 2008
- Engelska.
-
Ingår i: Cancer Genomics & Proteomics. - 1109-6535 .- 1790-6245. ; 5:6, s. 293-300
- Relaterad länk:
-
http://cgp.iiarjourn...
-
visa fler...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Patients with metastazing malignant melanoma have a poor outcome and determination of thickness of the primary tumor remains as the most important prognostic predictor. The aim of this study was to use an antibody-based proteomics strategy to search for new molecular markers associated with melanoma progression. Two proteins, TRP-1 and galectin-1, were identified as proteins with enhanced expression in cells from the melanocytic lineage. Patients and Methods: Protein profiling of TRP-1 and galectin-1 together with proliferation marker Ki-67 and melanocyte marker Melan-A was performed in normal tissues from 144 individuals and in 216 different tumors using tissue microarrays and immunohistochemistry. The protein expression pattern was further analyzed in a defined cohort of 157 patients diagnosed with invasive cutaneous malignant melanoma. Results: Both TRP-1 and galectin-1 were highly expressed in normal melanocytes and melanoma. The expression of TRP-1 was inversely correlated with tumor stage (p=0.002, (R=-0.28)). Neither TRP-1 or galectin-1 was associated with overall or disease free survival (p>0.14, p>0.46 respectively). Ki-67 was associated with tumor stage and survival (p<0.001). Conclusion: TRP-1 and galectin-1 protein expression patterns were determined in normal and cancer tissues and both proteins were expressed in the majority of the malignant melanomas. There was no correlation between TRP-1 or galectin-1 expression and survival.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
Nyckelord
- Galectin-1
- Human Protein Atlas Program
- Malignant melanoma
- TRP-1
- galectin 1
- glycoprotein
- Ki 67 antigen
- melan A
- molecular marker
- protein antibody
- protein TRP 1
- unclassified drug
- article
- cancer growth
- cancer staging
- cancer tissue
- controlled study
- disease free survival
- female
- human
- immunohistochemistry
- major clinical study
- male
- melanocyte
- melanoma
- overall survival
- protein analysis
- protein expression
- proteomics
- skin carcinogenesis
- tissue microarray
- Disease-Free Survival
- Follow-Up Studies
- Gene Expression Profiling
- Gene Expression Regulation
- Neoplastic
- Humans
- Ki-67 Antigen
- Melanocytes
- Membrane Glycoproteins
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Neoplasm Proteins
- Oxidoreductases
- Retrospective Studies
- Skin Neoplasms
- Survival Rate
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas