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Investigation of th...
Investigation of the elimination process of a multimodal polymer-shelled contrast agent in rats using ultrasound and transmission electron microscopy
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- Härmark, Johan (författare)
- KTH,Strukturell bioteknik,KTH, Strukturell bioteknik
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- Larsson, Malin K. (författare)
- KTH,Medicinsk bildteknik,KTH, Medicinsk bildteknik
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Razuvajev, Anton (författare)
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- Koeck, Philip JB (författare)
- KTH,Strukturell bioteknik,KTH, Strukturell bioteknik
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Paradossi, Gaio (författare)
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- Brodin, Lars-Åke (författare)
- KTH,Medicinsk bildteknik,KTH, Medicinsk bildteknik
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Caidahl, Kenneth (författare)
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- Hebert, Hans (författare)
- KTH,Strukturell bioteknik,KTH, Strukturell bioteknik
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- Bjällmark, Anna (författare)
- KTH,Medicinsk bildteknik,KTH, Medicinsk bildteknik
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(creator_code:org_t)
- 2015
- 2015
- Engelska.
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Ingår i: Biomedical Spectroscopy and Imaging. - 2212-8794. ; 4:1, s. 81-93
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: A novel polymer-shelled contrast agent (CA) with multimodal imaging and target specific potential was developed recently and tested for its acoustical properties using different in-vitro setups.OBJECTIVE: The aim of this study was to investigate the elimination of three types of the novel polymer-shelled CA, one unmodified and two shell modified versions, in rats.METHODS: The blood elimination time was estimated by measuring the image intensity, from ultrasound images of the common carotid artery, over time after a bolus injection of the three types of the novel CA. The commercially available CA SonoVue was used as a reference. The subcellular localization of the three CAs was investigated using transmission electron microscopy.RESULTS: The ultrasound measurements indicated a blood half-life of 17–85 s for the different types of the novel CA, which was significant longer than the blood half-life time for SonoVue. Additionally, CAs were exclusively found in the circulatory system, either taken up by, or found in the vicinity of macrophages.CONCLUSIONS: Compared to the commercially available CA SonoVue, the blood circulation times for the three types of the novel polymer-shelled CA were prolonged. Moreover, macrophages were suggested to be responsible for the elimination of the CA.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering (hsv//eng)
Nyckelord
- Contrast agent
- polymer
- subcellular localization
- transmission electron microscope
- ultrasound imaging
- Medical Technology
- Medicinsk teknologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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