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Neurotransmitter ph...
Neurotransmitter phenotype-specific expression changes in developing sympathetic neurons
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Apostolova, Galina (författare)
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Dorn, Roland (författare)
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- Ka, Sojeong (författare)
- Uppsala universitet,Institutionen för neurovetenskap
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- Hallböök, Finn (författare)
- Uppsala universitet,Medicinsk utvecklingsbiologi
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- Lundeberg, Joakim (författare)
- KTH,Genteknologi
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Liser, Keren (författare)
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Hakim, Vicky (författare)
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Brodski, Claude (författare)
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Michaelidis, Theologos M. (författare)
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Dechant, Georg (författare)
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- Engelska.
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Ingår i: Molecular and Cellular Neuroscience. - : Elsevier BV. - 1044-7431 .- 1095-9327. ; 35:3, s. 397-408
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- During late developmental phases individual sympathetic neurons undergo a switch from noradrenergic to cholinergic neurotransmission. This phenomenon of plasticity depends on target-derived signals in vivo and is triggered by neurotrophic factors in neuronal cultures. To analyze genome-wide expression differences between the two transmitter phenotypes we employed DNA microarrays. RNA expression profiles were obtained from chick paravertebral sympathetic ganglia, treated with neurotrophin 3, glial cell line-derived neurotrophic factor or ciliary neurotrophic factor, all of which stimulate cholinergic differentiation. Results were compared with the effect of nerve growth factor, which functions as a pro-noradrenergic stimulus. The gene set common to all three comparisons defined the noradrenergic and cholinergic synexpression groups. Several functional categories, such as signal transduction, G-protein-coupled signaling, cation transport, neurogenesis and synaptic transmission, were enriched in these groups. Experiments based on the prediction that some of the identified genes play a role in the neurotransmitter switch identified bone morphogenetic protein signaling as an inhibitor of cholinergic differentiation.
Nyckelord
- acetylcholine
- noradrenalin
- sympathetic
- neurotrophic
- Microarray
- nerve growth-factor
- cholinergic differentiation
- neural crest
- in-vivo
- ganglia
- system
- induction
- cytokines
- pathways
- signals
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Apostolova, Gali ...
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Dorn, Roland
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Ka, Sojeong
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Hallböök, Finn
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Lundeberg, Joaki ...
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Liser, Keren
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visa fler...
-
Hakim, Vicky
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Brodski, Claude
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Michaelidis, The ...
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Dechant, Georg
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visa färre...
- Artiklar i publikationen
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Molecular and Ce ...
- Av lärosätet
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Kungliga Tekniska Högskolan
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Uppsala universitet