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Pro-inflammatory Bl...
Pro-inflammatory Blood Markers and Heart Rate Variability in Apnoea as a Reflection of Basal Vagal Tone
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- Abtahi, Farhad, 1981- (författare)
- KTH,Medicinska sensorer, signaler och system,Karolinska Institutet, Sweden
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Hilderman, Marie (författare)
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Bruchfeld, Annette (författare)
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visa fler...
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- Seoane, Fernando (författare)
- KTH,Medicinska sensorer, signaler och system,University of Borås, Sweden
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- Janerot-Sjöberg, Birgitta (författare)
- KTH,Medicinsk bildteknik,Karolinska Institutet, Sweden
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- Lindecrantz, Kaj (författare)
- KTH,Medicinska sensorer, signaler och system,Karolinska Institutet, Sweden
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visa färre...
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(creator_code:org_t)
- Engelska.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Pro-inflammatory cytokines play a crucial role in inflammatory response, which istightly regulated by the nervous system to avoid the damage caused by inflammation. There isevidence for a cholinergic anti-inflammatory pathway that includes afferent and efferent vagalnerves that sense the inflammation and stimulate the anti-inflammatory response. Non-functionalanti-inflammatory response might lead to excessive and chronic inflammation e.g., rheumatoidarthritis (RA), inflammatory bowel disease (IBD), and poor outcome. Heart rate variability(HRV) has been proposed as a potential tool to monitor the level of anti-inflammatory activitythrough the monitoring of vagal activity. In this paper, the association of pro-inflammatorymarkers with HRV indices is evaluated. We used a database called “Heart Biomarker Evaluationin Apnea Treatment (HeartBEAT)” that consists of 6±2 hours of Electrocardiogram (ECG)recordings during nocturnal sleep from 318 patients at baseline and 301of them at 3 monthsfollow-up. HRV indices are calculated from ECG recordings of 5-360 minutes. The results showa statistically significant correlation between heart rate (HR) and pro-inflammatory cytokines,independent of duration of ECG analysis. HRV indices e.g., standard deviation of all RRintervals (SDNN) show an inverse relation to the pro-inflammatory cytokines. Longer ECGrecordings show a higher potential to reflect the level of anti-inflammatory response. In light oftheories for the cholinergic anti-inflammatory pathway, a combination of HR and HRV as areflection of basal vagal activity might be a potential prognostic tool for interventional guidance.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Annan medicinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Other Medical Engineering (hsv//eng)
Nyckelord
- Heart Rate Variability
- HRV
- cholinergic anti-inflammatory pathway
- basal vagal tone
- sampling of time-invariant system
- CRP
- pro-inflammatory blood markers
- inflammation
- Medicinsk teknologi
- Medical Technology
Publikations- och innehållstyp
- vet (ämneskategori)
- ovr (ämneskategori)