Sökning: id:"swepub:oai:DiVA.org:kth-195236" >
Inflammation-sensit...
Inflammation-sensitive in situ smart scaffolding for regenerative medicine
-
- Patra, Hirak Kumar (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Biosensorer och bioelektronik,Tekniska fakulteten
-
- Sharma, Y. (författare)
- International Center for Materials Nanoarchitectonics, National Institute for Materials Science (NIMS), Sengen, Tsukuba, Ibaraki, Japan
-
- Islam, Mohammad Mirazul (författare)
- Swedish Nanoscience Center, Karolinska Institute, Stockholm, Sweden
-
visa fler...
-
- Jafari, Mohammad Javad (författare)
- Linköpings universitet,Molekylär fysik,Tekniska fakulteten
-
- Natarajan Arul, Murugan (författare)
- KTH,Teoretisk kemi och biologi,Virtual Laboratory for Molecular Probes, Division of Theoretical Chemistry and Biology, School of Biotechnology, Royal Institute of Technology (KTH), Stockholm, Sweden
-
- Kobayashi, H. (författare)
- International Center for Materials Nanoarchitectonics, National Institute for Materials Science (NIMS), Sengen, Tsukuba, Ibaraki, Japan
-
- Turner, Anthony (författare)
- Linköpings universitet,Biosensorer och bioelektronik,Tekniska fakulteten
-
- Tiwari, Ashutosh (författare)
- Linköpings universitet,Biosensorer och bioelektronik,Tekniska fakulteten,International Center for Materials Nanoarchitectonics, National Institute for Materials Science (NIMS), Sengen, Tsukuba, Ibaraki, Japan ; Tekidag AB, UCS, Linköping, Sweden; Vinoba Bhave Research Institute, Saidabad, Allahabad, India
-
visa färre...
-
(creator_code:org_t)
- 2016
- 2016
- Engelska.
-
Ingår i: Nanoscale. - : Royal Society of Chemistry. - 2040-3364 .- 2040-3372. ; 8:39, s. 17213-17222
- Relaterad länk:
-
https://pubs.rsc.org...
-
visa fler...
-
https://liu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- To cope with the rapid evolution of the tissue engineering field, it is now essential to incorporate the use of on-site responsive scaffolds. Therefore, it is of utmost importance to find new 'Intelligent' biomaterials that can respond to the physicochemical changes in the microenvironment. In this present report, we have developed biocompatible stimuli responsive polyaniline-multiwalled carbon nanotube/poly(N-isopropylacrylamide), (PANI-MWCNT/PNIPAm) composite nanofiber networks and demonstrated the physiological temperature coordinated cell grafting phenomenon on its surface. The composite nanofibers were prepared by a two-step process initiated with an assisted in situ polymerization followed by electrospinning. To obtain a smooth surface in individual nanofibers with the thinnest diameter, the component ratios and electrospinning conditions were optimized. The temperature-gated rearrangements of the molecular structure are characterized by FTIR spectroscopy with simultaneous macromolecular architecture changes reflected on the surface morphology, average diameter and pore size as determined by scanning electron microscopy. The stimuli responsiveness of the nanofibers has first been optimized with computational modeling of temperature sensitive components (coil-like and globular conformations) to tune the mechanism for temperature dependent interaction during in situ scaffolding with the cell membrane. The nanofiber networks show excellent biocompatibility, tested with fibroblasts and also show excellent sensitivity to inflammation to combat loco-regional acidosis that delay the wound healing process by an in vitro model that has been developed for testing the proposed responsiveness of the composite nanofiber networks. Cellular adhesion and detachment are regulated through physiological temperature and show normal proliferation of the grafted cells on the composite nanofibers. Thus, we report for the first time, the development of physiological temperature gated inflammation-sensitive smart biomaterials for advanced tissue regeneration and regenerative medicine.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
Nyckelord
- Acrylic monomers
- Biocompatibility
- Biomaterials
- Carbon
- Carbon nanotubes
- Cell culture
- Cytology
- Electrospinning
- Fighter aircraft
- Fourier transform infrared spectroscopy
- Macromolecules
- Multiwalled carbon nanotubes (MWCN)
- Nanofibers
- Pathology
- Physiology
- Polyaniline
- Pore size
- Reconfigurable hardware
- Scanning electron microscopy
- Spinning (fibers)
- Tissue
- Tissue engineering
- Tissue regeneration
- Yarn
- Globular conformations
- In-situ polymerization
- Macromolecular architecture
- N- isopropylacrylamide
- Physico-chemical changes
- Physiological temperature
- Stimuli responsiveness
- Temperature-dependent interaction
- Scaffolds (biology)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas