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Rapid degradation o...
Abstract
Ämnesord
Stäng
- We have investigated the fate of the presequence of an overexpressed protein derived from the precursor of the F(1)beta subunit of ATP synthase after import and processing in mitochondria. Our studies revealed a rapid degradation of the presequence inside mitochondria catalysed by matrix-located protease(s). In contrast, the mature portion of the precursor was not degraded. This is the first experimental evidence of the rapid degradation of the F(1)beta a mitochondrial presequence in organello after in vitro import and processing.
Nyckelord
- protein import
- proteolysis
- signal peptide
- nitric-oxide synthase
- protein import
- processing peptidase
- thimet oligopeptidase
- synthetic presequence
- yeast mitochondria
- targeting peptides
- cleavage
- sequence
- binding
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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