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FZD10-Gα13 signalli...
FZD10-Gα13 signalling axis points to a role of FZD10 in CNS angiogenesis
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Hot, B. (författare)
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- Valnohova, J. (författare)
- Karolinska Institutet
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Arthofer, E. (författare)
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Simon, K. (författare)
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- Shin, J. (författare)
- Karolinska Institutet
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- Uhlén, Mathias (författare)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab
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Kostenis, E. (författare)
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- Mulder, J. (författare)
- Karolinska Institutet
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- Schulte, G. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier, 2017
- 2017
- Engelska.
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Ingår i: Cellular Signalling. - : Elsevier. - 0898-6568 .- 1873-3913. ; 32, s. 93-103
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Among the 10 Frizzled (FZD) isoforms belonging to the Class F of G protein-coupled receptors (GPCRs), FZD10 remains the most enigmatic. FZD10 shows homology to FZD4 and FZD9 and was previously implicated in both β-catenin-dependent and –independent signalling. In normal tissue, FZD10 levels are generally very low; however, its upregulation in synovial carcinoma has attracted some attention for therapy. Our findings identify FZD10 as a receptor interacting with and signalling through the heterotrimeric G protein Gα13 but not Gα12 Gαi1 GαoA Gαs, or Gαq. Stimulation with the FZD agonist WNT induced the dissociation of the Gα13 protein from FZD10, and led to global Gα12/13–dependent cell changes assessed by dynamic mass redistribution measurements. Furthermore, we show that FZD10 mediates Gα12/13 activation-dependent induction of YAP/TAZ transcriptional activity. In addition, we show a distinct expression of FZD10 in embryonic CNS endothelial cells at E11.5–E14.5. Given the well-known importance of Gα13 signalling for the development of the vascular system, the selective expression of FZD10 in brain vascular endothelial cells points at a potential role of FZD10-Gα13 signalling in CNS angiogenesis.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- Angiogenesis
- Endothelial cell
- FZD
- GNA13
- GPCR
- WNT
- YAP/TAZ
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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