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Isolation and Struc...
Isolation and Structural Characterization of Echinocystic Acid Triterpenoid Saponins from the Australian Medicinal and Food Plant Acacia ligulata
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Jaeger, Diana (författare)
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Ndi, Chi P. (författare)
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Crocoll, Christoph (författare)
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Simpson, Bradley S. (författare)
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Khakimov, Bekzod (författare)
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Guzman-Genuino, Ruth Marian (författare)
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Hayball, John D. (författare)
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- Xing, Xiaohui (författare)
- KTH,Glykovetenskap,School of Biotechnology, AlbaNova University Centre, Stockholm, SE-10691, Sweden; ARC Centre of Excellence in Plant Cell Walls, School of Agriculture, Food and Wine, The University of Adelaide, Waite Campus, Urrbrae, 5064, Australia
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- Bulone, Vincent (författare)
- KTH,Glykovetenskap,School of Biotechnology, AlbaNova University Centre, Stockholm, SE-10691, Sweden; ARC Centre of Excellence in Plant Cell Walls, School of Agriculture, Food and Wine, The University of Adelaide, Waite Campus, Urrbrae, 5064, Australia
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Weinstein, Philip (författare)
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Moller, Birger L. (författare)
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Semple, Susan J. (författare)
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(creator_code:org_t)
- 2017-10-04
- 2017
- Engelska.
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Ingår i: Journal of Natural Products. - : AMER CHEMICAL SOC. - 0163-3864 .- 1520-6025. ; 80:10, s. 2692-2698
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- The Australian plant Acacia ligulata has a number of traditional food and medicinal uses by Australian Aboriginal people, although no bioactive compounds have previously been isolated from this species. Bioassay-guided fractionation of an ethanolic extract of the mature pods of A. ligulata led to the isolation of the two new echinocystic acid triterpenoid saponins, ligulatasides A (1) and B (2), which differ in the fine structure of their glycan substituents. Their structures were elucidated on the basis of 1D and 2D NMR, GC-MS, LC-MS/MS, and saccharide linkage analysis. These are the first isolated compounds from A. ligulata and the first fully elucidated structures of triterpenoid saponins from Acacia sensu stricto having echinocystic acid reported as the aglycone. Compounds 1 and 2 were evaluated for cytotoxic activity against a human melanoma cancer cell line (SK-MEL28) and a diploid fibroblast cell line (HFF), but showed only weak activity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
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Jaeger, Diana
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Ndi, Chi P.
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Crocoll, Christo ...
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Simpson, Bradley ...
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Khakimov, Bekzod
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Guzman-Genuino, ...
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visa fler...
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Hayball, John D.
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Xing, Xiaohui
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Bulone, Vincent
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Weinstein, Phili ...
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Moller, Birger L ...
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Semple, Susan J.
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visa färre...
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