Sensing Spindle Neurons in the Insula with Multi-shell Diffusion MRI

• Sensing microstructural characteristics of human brain tissue with clinical scanners has been an area of heated debate in the diffusion MRI (dMRI) community. In this work, we propose that diffusion MRI on clinical scanners is sensitive to the presence of spindle neurons.Spindle neurons, located in the insular and anterior cingular cortices, are only present in mammals with high cognitive functions. Albeit this neurons' role is not yet known, evidence suggests they facilitate rapid long-range information integration.In this work, we provide theoretical and in-silico evidence that the dMRI signal is sensitive to the presence of spindle neurons as well as preliminary evidence on human dMRI images. 

Nyckelord

Tillämpad matematik och beräkningsmatematik

Applied and Computational Mathematics

Tillämpad medicinsk teknik

Applied Medical Technology

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