Numerical study of a cylinder model of diffusion MRI signal for neuronal dendrite trees

• We study numerically how the neuronal dendrite tree structure can affect the diffusion magnetic resonance imaging (dMRI) signal in brain tissue. For a large set of randomly generated dendrite trees, synthetic dMRI signals are computed and fitted to a cylinder model to estimate the effective longitudinal diffusivity DL in the direction of neurites. When the dendrite branches are short compared to the diffusion length, DL depends significantly on the ratio between the average branch length and the diffusion length. In turn, DL has very weak dependence on the distribution of branch lengths and orientations of a dendrite tree, and the number of branches per node. We conclude that the cylinder model which ignores the connectivity of the dendrite tree can still be adapted to describe the apparent diffusion coefficient in brain tissue.

Ämnesord

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

Nyckelord

Diffusion MRI

Cylinder model

Neurites

Dendrite trees

Tillämpad matematik och beräkningsmatematik

Applied and Computational Mathematics

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)