Elevated levels of insulin-like growth factor-binding protein 1 predict outcome after acute myocardial infarction : A long-term follow-up of the glucose tolerance in patients with acute myocardial infarction (GAMI) cohort

• Objective: To investigate the long-term prognostic value of insulin-like growth factor-binding protein 1 in patients with acute myocardial infarction. Methods: Patients (n = 180) with admission glucose < 11 mmol/L without previously known diabetes admitted for an acute myocardial infarction in 1998–2000 were followed for mortality and cardiovascular events (first of cardiovascular mortality/acute myocardial infarction/stroke/severe heart failure) until the end of 2011 (median 11.6 years). Fasting levels of insulin-like growth factor-binding protein 1 at day 2 were related to outcome in Cox proportional hazard regression analyses. Results: Median age was 64 years, 69% were male and median insulin-like growth factor-binding protein 1 was 20 µg/L. Total mortality was 34% (n = 61) and 44% (n = 80) experienced a cardiovascular event during a median follow-up time of 11.6 years. After age adjustment, insulin-like growth factor-binding protein 1 was associated with all-cause (1.40; 1.02–1.93, p = 0.039) and cancer mortality (2.09; 1.15–3.79, p = 0.015) but not with cardiovascular death (p = 0.29) or cardiovascular events (p = 0.57). After adjustments also for previous myocardial infarction, previous heart failure and body mass index, insulin-like growth factor-binding protein 1 was still associated with all-cause mortality (1.38; 1.01–1.89, p = 0.046). Conclusion: In patients with acute myocardial infarction without previously known diabetes, high insulin-like growth factor-binding protein 1 was associated with long-term all-cause and cancer mortality but not with cardiovascular events.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

abnormal glucose tolerance

Acute myocardial infarction

insulin-like growth factor-binding protein 1

prognosis

glucose

hemoglobin A1c

insulin

lipid

proinsulin

somatomedin binding protein 1

somatomedin C

biological marker

IGFBP1 protein

human

acute heart infarction

adult

aged

all cause mortality

Article

body mass

cancer mortality

cardiovascular mortality

cerebrovascular accident

cohort analysis

controlled study

disease severity

fasting

female

follow up

glucose blood level

glucose tolerance

heart failure

hospital admission

human

insulin blood level

lipid blood level

long term care

major clinical study

male

outcome assessment

protein blood level

blood

cause of death

chi square distribution

disease exacerbation

heart infarction

Kaplan Meier method

metabolism

middle aged

mortality

neoplasm

proportional hazards model

risk factor

time factor

upregulation

Biomarkers

Blood Glucose

Chi-Square Distribution

Disease Progression

Follow-Up Studies

Humans

Insulin-Like Growth Factor Binding Protein 1

Kaplan-Meier Estimate

Myocardial Infarction

Neoplasms

Proportional Hazards Models

Risk Factors

Time Factors

Up-Regulation

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