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Forces drive baseme...
Forces drive basement membrane invasion in Caenorhabditis elegans
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- Caceres, Rodrigo (författare)
- PSL Res Univ, CNRS, Lab Physicochim Curie, Inst Curie, F-75005 Paris, France.;Univ Paris 05, F-75005 Paris, France.;Sorbonne Univ, F-75005 Paris, France.
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- Bojanala, Nagagireesh (författare)
- PSL Res Univ, CNRS, Lab Physicochim Curie, Inst Curie, F-75005 Paris, France.;Sorbonne Univ, F-75005 Paris, France.
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- Kelley, Laura C. (författare)
- Duke Univ, Dept Biol, Regenerat Next, Durham, NC 27705 USA.
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- Dreier, Jes (författare)
- KTH,Tillämpad fysik,Science for Life Laboratory, SciLifeLab
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- Manzi, John (författare)
- PSL Res Univ, CNRS, Lab Physicochim Curie, Inst Curie, F-75005 Paris, France.;Sorbonne Univ, F-75005 Paris, France.
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- Di Federico, Fahima (författare)
- PSL Res Univ, CNRS, Lab Physicochim Curie, Inst Curie, F-75005 Paris, France.;Sorbonne Univ, F-75005 Paris, France.
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- Chi, Qiuyi (författare)
- Duke Univ, Dept Biol, Regenerat Next, Durham, NC 27705 USA.
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- Risler, Thomas (författare)
- PSL Res Univ, CNRS, Lab Physicochim Curie, Inst Curie, F-75005 Paris, France.;Sorbonne Univ, F-75005 Paris, France.
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- Testa, Ilaria (författare)
- KTH,Tillämpad fysik,Science for Life Laboratory, SciLifeLab
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- Sherwood, David R. (författare)
- Duke Univ, Dept Biol, Regenerat Next, Durham, NC 27705 USA.
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- Plastino, Julie (författare)
- PSL Res Univ, CNRS, Lab Physicochim Curie, Inst Curie, F-75005 Paris, France.;Sorbonne Univ, F-75005 Paris, France.
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PSL Res Univ, CNRS, Lab Physicochim Curie, Inst Curie, F-75005 Paris, France;Univ Paris 05, F-75005 Paris, France.;Sorbonne Univ, F-75005 Paris, France. PSL Res Univ, CNRS, Lab Physicochim Curie, Inst Curie, F-75005 Paris, France.;Sorbonne Univ, F-75005 Paris, France. (creator_code:org_t)
- 2018-10-22
- 2018
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 115:45, s. 11537-11542
- Relaterad länk:
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https://www.pnas.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- During invasion, cells breach basement membrane (BM) barriers with actin-rich protrusions. It remains unclear, however, whether actin polymerization applies pushing forces to help break through BM, or whether actin filaments play a passive role as scaffolding for targeting invasive machinery. Here, using the developmental event of anchor cell (AC) invasion in Caenorhabditis elegans, we observe that the AC deforms the BM and underlying tissue just before invasion, exerting forces in the tens of nanonewtons range. Deformation is driven by actin polymerization nucleated by the Arp2/3 complex and its activators, whereas formins and cross-inkers are dispensable. Delays in invasion upon actin regulator loss are not caused by defects in AC polarity, trafficking, or secretion, as appropriate markers are correctly localized in the AC even when actin is reduced and invasion is disrupted. Overall force production emerges from this study as one of the main tools that invading cells use to promote BM disruption in C. elegans.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Annan teknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Other Engineering and Technologies (hsv//eng)
Nyckelord
- actin cytoskeleton
- force production
- cell invasion
- Arp2/3 complex
- anchor cell
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Caceres, Rodrigo
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Bojanala, Nagagi ...
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Kelley, Laura C.
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Dreier, Jes
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Manzi, John
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Di Federico, Fah ...
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visa fler...
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Chi, Qiuyi
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Risler, Thomas
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Testa, Ilaria
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Sherwood, David ...
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Plastino, Julie
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visa färre...
- Om ämnet
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Annan teknik
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Kungliga Tekniska Högskolan