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Carbon dioxide-cata...
Carbon dioxide-catalyzed peroxynitrite reactivity - The resilience of the radical mechanism after two decades of research
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- Augusto, Ohara (författare)
- Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-5508000 Sao Paulo, Brazil.
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- Goldstein, Sara (författare)
- Hebrew Univ Jerusalem, Chem Inst, IL-91904 Jerusalem, Israel.
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- Hurst, James K. (författare)
- Oregon State Univ, Dept Biochem & Biophys, Corvallis, OR 97331 USA.
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- Lind, Johan (författare)
- KTH,Skolan för kemi, bioteknologi och hälsa (CBH)
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- Lymar, Sergei, V (författare)
- Brookhaven Natl Lab, Dept Chem, Upton, NY 11973 USA.
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- Merényi, Gabor (författare)
- KTH,Tillämpad fysikalisk kemi
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- Radi, Rafael (författare)
- Univ Republica, Dept Bioquim, Fac Med, Montevideo 11800, Uruguay.;Univ Republica, Ctr Free Rad & Biomed Res, Fac Med, Montevideo 11800, Uruguay.
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Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-5508000 Sao Paulo, Brazil Hebrew Univ Jerusalem, Chem Inst, IL-91904 Jerusalem, Israel. (creator_code:org_t)
- ELSEVIER SCIENCE INC, 2019
- 2019
- Engelska.
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Ingår i: Free Radical Biology & Medicine. - : ELSEVIER SCIENCE INC. - 0891-5849 .- 1873-4596. ; 135, s. 210-215
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Peroxynitrite, ONOO-, formed in tissues that are simultaneously generating NO center dot and O-2(center dot-), is widely regarded as a major contributor to oxidative stress. Many of the reactions involved are catalyzed by CO2 via formation of an unstable adduct, ONOOC(O)O-, that undergoes O-O bond homolysis to produce NO2 center dot and CO3 center dot- radicals, whose yields are equal at about 0.33 with respect to the ONOO- reactant. Since its inception two decades ago, this radical-based mechanism has been frequently but unsuccessfully challenged. The most recent among these [Serrano-Luginbuehl et al. Chem. Res. Toxicol. 31: 721-730; 2018] claims that ONOOC(O)O- is stable, predicts a yield of NO2 center dot/CO3 center dot- of less than 0.01 under physiological conditions and, contrary to widely accepted viewpoints, suggests that radical generation is inconsequential to peroxynitrite-induced oxidative damage. Here we review the experimental and theoretical evidence that support the radical model and show this recently proposed alternative mechanism to be incorrect.
Ämnesord
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
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