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Nailfold microvascu...
Nailfold microvascular changes in patients with systemic lupus erythematosus and their associative factors
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- Fatemi, Alimohammad (författare)
- Isfahan Univ Med Sci, Sch Med, Dept Internal Med, Rheumatol Sect, Esfahan, Iran.,Isfahan University of Medical Sciences, Isfahan, Iran
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- Erlandsson, Björn-Erik (författare)
- KTH,Medicinteknik och hälsosystem,KTH Royal Institute of Technology
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- Emrani, Zahra (författare)
- Isfahan Univ Med Sci, Sch Med, Dept Med Phys, Esfahan, Iran.,Isfahan University of Medical Sciences, Isfahan, Iran
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- Etehadtavakol, Mahnaz (författare)
- Isfahan Univ Med Sci, Sch Med, Dept Med Phys, Esfahan, Iran.,Isfahan University of Medical Sciences, Isfahan, Iran
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- Smiley, Abbas (författare)
- Indiana Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Bloomington, IN USA.,Indiana University, Bloomington, IN, USA
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- Karbalaie, Abdolamir, 1975- (författare)
- KTH,Medicinteknik och hälsosystem,KTH Royal Institute of Technology
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Isfahan Univ Med Sci, Sch Med, Dept Internal Med, Rheumatol Sect, Esfahan, Iran Isfahan University of Medical Sciences, Isfahan, Iran (creator_code:org_t)
- ACADEMIC PRESS INC ELSEVIER SCIENCE, 2019
- 2019
- Engelska.
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Ingår i: Microvascular Research. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 0026-2862 .- 1095-9319. ; 126
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Objectives: The aim of this study was to determine capillaroscopic changes in patients with systemic lupus erythematosus (SLE) and their predictors. Methods: Fifty-nine SLE patients and 31 controls were enrolled in a cross-sectional study. Nailfold capillaroscopy examinations were performed, and qualitative semi-quantitative and quantitative parameters were evaluated in all fingers. Demographic features and lupus characteristics, such as renal involvement, medications, laboratory data, disease activity (SLEDAI) and damage, were recorded. The predictors of capillaroscopic abnormalities were obtained by backward stepwise regression analysis. Results: Capillary numbers of right hands were significantly lower in patients than in controls [8.74 (1.66) vs. 9.63 (1.80), P = 0.0001]. Capillaries were wider in patients than in controls in right [56.32 pm (16.76) vs. 50.43 mu m (10.16), P = 0.002] and left hands [54.40 (15.02) vs. 49.71 (9.77), P = 0.005]. Capillaries were shorter in SLE patients than in controls. Multivariate analysis revealed that the main associative factors of microvascular abnormalities were gender, drinking tea and hydroxychloroquine use for giant capillaries, SLEDAI and low C3 for avascularity and age, lupus nephritis and corticosteroid use for ramification. Conclusion: Most nailfold capillaroscopic abnormalities were more common in SLE patients than in controls. Hydroxychloroquine, corticosteroids, SLEDAI, low complement and lupus nephritis may be the major prognostic factors for microvascular changes in SLE patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Nailfold video capillaroscopy
- Systemic lupus erythematosus
- Microcirculation
- Technology and Health
- Teknik och hälsa
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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