Sökning: id:"swepub:oai:DiVA.org:kth-27253" >
Botulinumtoxin A tr...
Botulinumtoxin A treatment in toddlers with cerebral palsy
-
- Tedroff, K. (författare)
- Karolinska Institutet
-
- Lowing, K. (författare)
- Karolinska Institutet
-
- Haglund-Akerlind, Y. (författare)
- Karolinska Institutet
-
visa fler...
-
- Gutierrez-Farewik, Elena (författare)
- Karolinska Institutet,KTH,Strukturmekanik
-
- Forssberg, H. (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2010-03-11
- 2010
- Engelska.
-
Ingår i: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 99:8, s. 1156-1162
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Aims: In this study the aim was to evaluate the effect of botulinum toxin A (BoNT-A) treatment on muscle tone, contracture development and gait pattern in young children with cerebral palsy (CP). Method: Fifteen children with spastic CP (mean age = 16 months) were included in a randomized control study. All received a daily stretching programme and children in the BoNT-A group additionally received two injections, 6 months apart in the gastrocnemius muscle. Outcomes were assessed at baseline, and after 1 and 3.5 years. A 3D gait-analysis was performed at 5 years of age. Results: Plantarflexor muscle tone in the BoNT-A group was significantly reduced after 3.5 years, while the muscle tone at the ankle and knee in the control group remained unchanged. The change-score in knee-flexion muscle tone between the groups was significantly different after 3.5 years. The knee joint ROM was significantly increased at 1 year in the BoNT-A group but reduced at the knee and ankle joints in the control group after 3.5 years. No group differences were found for gait analysis, GMFM-66 or PEDI. Conclusion: Early treatment of BoNT-A in children with spastic CP may decrease muscle tone and decelerate contracture development after 3.5 years. The effect on gait development remains inconclusive.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Botulinum toxin A
- Cerebral palsy
- Contracture
- Gait
- Long term
- Paediatric medicine
- Pediatrisk medicin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas