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Epiphyseal Cartilag...
Epiphyseal Cartilage Formation Involves Differential Dynamics of Various Cellular Populations During Embryogenesis
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- Zhang, Yi (författare)
- Cent South Univ, Xiangya Hosp, Dept Orthopaed, Changsha, Peoples R China.;Karolinska Inst, Dept Physiol & Pharmacol, Solna, Sweden.
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- Annusver, Karl (författare)
- Karolinska Institutet
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- Sunadome, Kazunori (författare)
- Karolinska Inst, Dept Physiol & Pharmacol, Solna, Sweden.
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- Kameneva, Polina (författare)
- Karolinska Inst, Dept Physiol & Pharmacol, Solna, Sweden.
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- Edwards, Steven (författare)
- KTH,Biofysik,Science for Life Laboratory, SciLifeLab
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- Lei, Guanghua (författare)
- Cent South Univ, Xiangya Hosp, Dept Orthopaed, Changsha, Peoples R China.
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- Kasper, Maria (författare)
- Karolinska Institutet
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- Chagin, Andrei S. (författare)
- Karolinska Institutet
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- Adameyko, Igor (författare)
- Karolinska Institutet
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- Xie, Meng (författare)
- Karolinska Institutet
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Karolinska Institutet Cent South Univ, Xiangya Hosp, Dept Orthopaed, Changsha, Peoples R China;Karolinska Inst, Dept Physiol & Pharmacol, Solna, Sweden. (creator_code:org_t)
- 2020-03-05
- 2020
- Engelska.
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Ingår i: Frontiers in Cell and Developmental Biology. - : FRONTIERS MEDIA SA. - 2296-634X. ; 8
- Relaterad länk:
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https://doi.org/10.3...
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https://www.frontier...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- A joint connects two or more bones together to form a functional unit that allows different types of bending and movement. Little is known about how the opposing ends of the connected bones are developed. Here, applying various lineage tracing strategies we demonstrate that progenies of Gdf5-, Col2-, Prrx1-, and Gli1-positive cells contribute to the growing epiphyseal cartilage in a spatially asymmetrical manner. In addition, we reveal that cells in the cartilaginous anlagen are likely to be the major sources for epiphyseal cartilage. Moreover, Gli1-positive cells are found to proliferate along the skeletal edges toward the periarticular region of epiphyseal surface. Finally, a switch in the mechanism of growth from cell division to cell influx likely occurs in the epiphyseal cartilage when joint cavitation has completed. Altogether, our findings reveal an asymmetrical mechanism of growth that drives the formation of epiphyseal cartilage ends, which might implicate on how the articular surface of these skeletal elements acquires their unique and sophisticated shape during embryonic development.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- joint
- cartilage
- clonal tracing
- asymmetrical
- dynamics
- embryonic development
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Zhang, Yi
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Annusver, Karl
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Sunadome, Kazuno ...
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Kameneva, Polina
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Edwards, Steven
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Lei, Guanghua
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visa fler...
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Kasper, Maria
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Chagin, Andrei S ...
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Adameyko, Igor
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Xie, Meng
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Cell och molekyl ...
- Artiklar i publikationen
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Frontiers in Cel ...
- Av lärosätet
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Kungliga Tekniska Högskolan
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Karolinska Institutet