Enantioselective Synthesis of anti-beta-Hydroxy-alpha-amido Esters via Transfer Hydrogenation

• The asymmetric transfer hydrogenation of alpha-amido-beta-keto esters to provide the corresponding anti-beta-hydroxy-alpha-amido esters in good to excellent yields, diastereoselectivity, and enantioselectivity is reported. The procedure is operationally simple, and delicate handling of the catalyst is not necessary.

Ämnesord

NATURVETENSKAP  -- Kemi -- Organisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Organic Chemistry (hsv//eng)

Nyckelord

dynamic kinetic resolution

asymmetric transfer hydrogenation

amino acid-derivatives

aldol reactions

stereoselective hydrogenation

catalyzed hydrogenation

functionalized ketones

efficient approach

organic-synthesis

aldehydes

Organic chemistry

Organisk kemi

Publikations- och innehållstyp

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