Cooperative Silver- and Base-Catalyzed Diastereoselective Cycloaddition of Nitrones with Methylene Isocyanides : Access to 2-Imidazolinones

• A protocol involving cooperative silver- and base-catalyzed diastereoselective cycloaddition of nitrones with isocyanides is described, providing access to a wide range of 2-imidazolinone derivatives with various functional groups as single diastereomers. Varying the base and temperature of the reaction allowed selective access to both diastereomers of the product. A plausible reaction mechanism is proposed and supported by DFT calculations. 

Ämnesord

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

Nyckelord

Diastereoselectivity

Imidazolinones

Isocyanides

Nitrones

Silver

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