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Skeletal Muscle Tra...
Skeletal Muscle Transcriptomic Comparison between Long-Term Trained and Untrained Men and Women
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- Chapman, Mark A. (författare)
- Univ San Diego, Dept Integrated Engn, San Diego, CA 92110 USA.;Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
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- Arif, Muhammad (författare)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab
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- Emanuelsson, Eric B. (författare)
- Karolinska Institutet
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- Reitzner, Stefan M. (författare)
- Karolinska Institutet
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- Lindholm, Malene E. (författare)
- Karolinska Institutet
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- Mardinoglu, Adil (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England.
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- Sundberg, Carl Johan (författare)
- Karolinska Institutet
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Univ San Diego, Dept Integrated Engn, San Diego, CA 92110 USA;Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden. Systembiologi (creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska.
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Ingår i: Cell Reports. - : Elsevier BV. - 2211-1247. ; 31:12
- Relaterad länk:
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https://doi.org/10.1...
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- To better understand the health benefits of lifelong exercise in humans, we conduct global skeletal muscle transcriptomic analyses of long-term endurance- (9 men, 9 women) and strength-trained (7 men) humans compared with age-matched untrained controls (7 men, 8 women). Transcriptomic analysis, Gene Ontology, and genome-scale metabolic modeling demonstrate changes in pathways related to the prevention of metabolic diseases, particularly with endurance training. Our data also show prominent sex differences between controls and that these differences are reduced with endurance training. Additionally, we compare our data with studies examining muscle gene expression before and after a months-long training period in individuals with metabolic diseases, This analysis reveals that training shifts gene expression in individuals with impaired metabolism to become more similar to our endurance-trained group. Overall, our data provide an extensive examination of the accumulated transcriptional changes that occur with decades-long training and identify important "exercise-responsive" genes that could attenuate metabolic disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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