Selective neuromodulation and mutual inhibition within the CA3–CA2 system can prioritize sequences for replay

• To make optimal use of previous experiences, important neural activity sequences must be prioritized during hippocampal replay. Integrating insights about the interplay between CA3 and CA2, we propose a conceptual framework that allows the two regions to control which sequences are reactivated. We suggest that neuromodulatory-gated plasticity and mutual inhibition enable discrete assembly sequences in both regions to support each other while suppressing competing sequences. This perspective provides a coherent interpretation for a variety of seemingly disconnected functional properties of CA2 and paves the way for a more general understanding of CA2.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Nyckelord

CA2

CA3

conceptual framework

consolidation

controlled study

hippocampal CA2 region

hippocampal CA3 region

hippocampus

human

neuromodulation

note

sequence prioritization

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)