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Multimodal Imaging ...
Multimodal Imaging of Pancreatic Ductal Adenocarcinoma Using Multifunctional Nanoparticles as Contrast Agents
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- Zhao, Ying (författare)
- Karolinska Institutet
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- Ye, Fei (författare)
- Karolinska Inst, Div Expt Canc Med, Dept Lab Med LABMED, SE-14186 Stockholm, Sweden.
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- Brismar, Torkel B. (författare)
- Karolinska Institutet
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- Li, Xuan (författare)
- Karolinska Inst, Dept Clin Sci Intervent & Technol CLINTEC, Pancreat Canc Res Lab, SE-14186 Stockholm, Sweden.
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- He, Rui (författare)
- Karolinska Institutet
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- Heuchel, Rainer (författare)
- Karolinska Institutet
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- El-Sayed, Ramy (författare)
- Karolinska Inst, Div Expt Canc Med, Dept Lab Med LABMED, SE-14186 Stockholm, Sweden.
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- Feliu, Neus (författare)
- Karolinska Inst, Div Expt Canc Med, Dept Lab Med LABMED, SE-14186 Stockholm, Sweden.;Univ Hamburg, Ctr Hybrid Nanostruct CHyN, D-22607 Hamburg, Germany.
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- Zheng, Wenyi (författare)
- Karolinska Institutet
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- Oerther, Sandra (författare)
- Karolinska Institutet
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- Dutta, Joydeep, Professor, 1964- (författare)
- KTH,Material- och nanofysik
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- Parak, Wolfgang J. (författare)
- Univ Hamburg, Ctr Hybrid Nanostruct CHyN, D-22607 Hamburg, Germany.
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- Muhammed, Mamoun (författare)
- Karolinska Institutet,KTH,Alexandria Univ, Inst Grad Studies & Res IGSR, Alexandria 21526, Egypt.
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- Hassan, Moustapha (författare)
- Karolinska Inst, Div Expt Canc Med, Dept Lab Med LABMED, SE-14186 Stockholm, Sweden.;Karolinska Univ Hosp Huddinge, Clin Res Ctr, SE-14186 Stockholm, Sweden.;Karolinska Univ Hosp Huddinge, Ctr Allogene Stem Cell Transplantat CAST, SE-14186 Stockholm, Sweden.;Alexandria Univ, Inst Grad Studies & Res IGSR, Alexandria 21526, Egypt.
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Karolinska Institutet Karolinska Inst, Div Expt Canc Med, Dept Lab Med LABMED, SE-14186 Stockholm, Sweden (creator_code:org_t)
- 2020-11-17
- 2020
- Engelska.
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Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 12:48, s. 53665-53681
- Relaterad länk:
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https://doi.org/10.1...
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https://pubs.acs.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Late diagnosis and refractory behavior toward current treatment protocols make pancreatic ductal adenocarcinoma (PDAC) one of the most difficult cancer forms to treat. The imaging-based approach plays an important role to identify potentially curable PDAC patients in high-risk groups at the early stage. In the present study, we developed a core-shell structured gold nanorod (AuNR) as a contrast agent for multimodal imaging and investigated its application for PDAC diagnosis. The composite nanopartides composed of a AuNR core inside a layer of mesoporous silica that was then coated with a gadolinium oxide carbonate shell (AuNR-SiO2 -Gd) are designed to be used in magnetic resonance imaging (MRI), X-ray computed tomography (CT), and photoacoustic imaging (PM). A phantom study with the AuNR-SiO2-Gd NPs demonstrated higher MRI contrast compared to Gadovist and higher X-ray attenuation than Visipaque. A strong, stable, and broad wavelength range signal with a peak at 800 nm was observed in PAI. The AuNR-SiO2-Gd NPs showed significant contrast enhancement under PAI/MRI/CT in both the liver and spleen of control mice after intravenous administration. The utility in PDAC was studied in a genetically engineered mouse model carrying Kras and p53 mutations, which develops spontaneous tumors and keeps the desmoplasia and hypovascularity feature of PDAC in patients. The AuNR-SiO2-Gd NPs were highly accumulated in the surrounding soft tissues but were sparsely distributed throughout the tumor due to dense stroma infiltration and poor tumor vascularization. Hence, a negative contrast within the tumor area in CT/PAI and a positive contrast in MRI were observed. In conclusion, AuNR-SiO2-Gd NPs have good potential to be developed as a multimodal contrast agent for PDAC, which might improve early diagnosis and benefit the clinical outcome for PDAC patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- multimodal
- magnetic resonance imaging
- computed tomography
- photoacoustic imaging
- pancreatic ductal adenocarcinoma
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Zhao, Ying
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Ye, Fei
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Brismar, Torkel ...
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Li, Xuan
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He, Rui
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Heuchel, Rainer
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El-Sayed, Ramy
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Feliu, Neus
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Zheng, Wenyi
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Oerther, Sandra
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Dutta, Joydeep, ...
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Parak, Wolfgang ...
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Muhammed, Mamoun
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Hassan, Moustaph ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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ACS Applied Mate ...
- Av lärosätet
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Kungliga Tekniska Högskolan
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Karolinska Institutet