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Genotoxicity and in...
Genotoxicity and inflammatory potential of stainless steel welding fume particles : an in vitro study on standard vs Cr(VI)-reduced flux-cored wires and the role of released metals
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- McCarrick, Sarah (författare)
- Karolinska Institutet
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- Romanovski, Valentin (författare)
- KTH,Yt- och korrosionsvetenskap,Natl Univ Sci & Technol, Ctr Funct Nanoceram, MISIS, Moscow 119049, Russia.;Natl Acad Sci Belarus, Inst Gen & Inorgan Chem, Minsk 220072, BELARUS.
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- Wei, Zheng (författare)
- KTH,Yt- och korrosionsvetenskap,Univ Western Ontario, Dept Chem, London, ON N6A 5B7, Canada.
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- Westin, Elin M. (författare)
- Voestalpine Bohler Welding GmbH, Bohler Welding Str 1, A-8605 Kapfenberg, Austria.
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- Persson, Kjell-Arne (författare)
- Swerim, S-16407 Kista, Sweden.
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- Trydell, Klara (författare)
- Swerim, S-16407 Kista, Sweden.
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- Wagner, Richard (författare)
- Linde GmbH UniBw Munich, Munich, Germany.
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- Odnevall Wallinder, Inger, 1965- (författare)
- KTH,Yt- och korrosionsvetenskap,Karolinska Inst, AIMES Ctr Adv Integrated Med & Engn Sci, Stockholm, Sweden.;KTH Royal Inst Technol, Stockholm, Sweden.;Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden.
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- Hedberg, Yolanda, Docent, 1985- (författare)
- KTH,Yt- och korrosionsvetenskap,Univ Western Ontario, Dept Chem, London, ON N6A 5B7, Canada.;Univ Western Ontario, Surface Sci Western, London, ON N6G 0J3, Canada.;Lawson Hlth Res Inst, London, ON N6C2R5, Canada.
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- Karlsson, Hanna L. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-07-21
- 2021
- Engelska.
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Ingår i: Archives of Toxicology. - : Springer Nature. - 0340-5761 .- 1432-0738. ; 95:9, s. 2961-2975
- Relaterad länk:
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https://doi.org/10.1...
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https://link.springe...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Welders are daily exposed to various levels of welding fumes containing several metals. This exposure can lead to an increased risk for different health effects which serves as a driving force to develop new methods that generate less toxic fumes. The aim of this study was to explore the role of released metals for welding particle-induced toxicity and to test the hypothesis that a reduction of Cr(VI) in welding fumes results in less toxicity by comparing the welding fume particles of optimized Cr(VI)-reduced flux-cored wires (FCWs) to standard FCWs. The welding particles were thoroughly characterized, and toxicity (cell viability, DNA damage and inflammation) was assessed following exposure to welding particles as well as their released metal fraction using cultured human bronchial epithelial cells (HBEC-3kt, 5-100 mu g/mL) and human monocyte-derived macrophages (THP-1, 10-50 mu g/mL). The results showed that all Cr was released as Cr(VI) for welding particles generated using standard FCWs whereas only minor levels (< 3% of total Cr) were released from the newly developed FCWs. Furthermore, the new FCWs were considerably less cytotoxic and did not cause any DNA damage in the doses tested. For the standard FCWs, the Cr(VI) released in cell media seemed to explain a large part of the cytotoxicity and DNA damage. In contrast, all particles caused rather similar inflammatory effects suggesting different underlying mechanisms. Taken together, this study suggests a potential benefit of substituting standard FCWs with Cr(VI)-reduced wires to achieve less toxic welding fumes and thus reduced risks for welders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Nanoparticles
- Cytokines
- Comet assay
- Cytotoxicity
- Metal release
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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