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Cardiac troponin T ...
Cardiac troponin T is elevated and increases longitudinally in ALS patients
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- Kläppe, U. (author)
- Karolinska Institutet
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Chamoun, S. (author)
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- Shen, Q. (author)
- Karolinska Institutet
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Finn, A. (author)
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Evertsson, B. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Press, R. (author)
- Karolinska Institutet
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- Samuelsson, K. (author)
- Karolinska Institutet
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- Månberg, Anna, 1985- (author)
- KTH,Affinitets-proteomik
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- Fang, F. (author)
- Karolinska Institutet
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- Ingre, C. (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-06-21
- 2022
- English.
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In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. - : Taylor and Francis Ltd.. - 2167-8421 .- 2167-9223. ; 23:1-2, s. 58-65
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Abstract
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- Objective: To test whether high-sensitivity cardiac troponin T (hs-cTnT) could act as a diagnostic or prognostic biomarker in ALS, comparing hs-cTnT to neurofilament light (NfL). Methods: We performed a case-control study, including 150 ALS patients, 28 ALS mimics, and 108 healthy controls, and a follow-up study of the ALS patients, during 2014–2020 in Stockholm, Sweden. We compared concentrations of hs-cTnT in plasma and NfL in the cerebrospinal fluid between cases and controls. To evaluate the diagnostic performance, we calculated the area under the curve (AUC). Hazard ratios (HRs) were estimated from Cox models to assess associations between hs-cTnT and NfL at ALS diagnosis and risk of death. The longitudinal analysis measured changes of hs-cTnT and NfL since ALS diagnosis. Results: We noted higher levels of hs-cTnT in ALS patients (median: 16.5 ng/L) than in ALS mimics (11 ng/L) and healthy controls (6 ng/L). Both hs-cTnT and NfL could distinguish ALS patients from ALS mimics, with higher AUC noted for NfL (AUC 0.88; 95%CI 0.79–0.97). Disease progression correlated weakly with hs-cTnT (Pearson’s r = 0.18, p = 0.04) and moderately with NfL (Pearson’s r = 0.41, p < 0.001). Shorter survival was associated with higher levels of NfL at diagnosis (HR 1.08, 95%CI 1.04–1.11), but not hs-cTnT. hs-cTnT increased (12.61 ng/L per year, 95%CI 7.14–18.06) whereas NfL decreased longitudinally since ALS diagnosis. Conclusions: NfL is a stronger diagnostic and prognostic biomarker than hs-cTnT for ALS. However, hs-cTnT might constitute a disease progression biomarker as it increases longitudinally. The underlying causes for this increase need to be investigated.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- amyotrophic lateral sclerosis
- cardiac troponin T
- Case-control study
- follow-up study
- neurofilament proteins
- neurofilament protein
- troponin T
- adult
- aged
- Amyotrophic Lateral Sclerosis Functional Rating Scale
- area under the curve
- Article
- body mass
- case control study
- cerebrospinal fluid
- cohort analysis
- comparative study
- controlled study
- diagnostic test accuracy study
- disease exacerbation
- enzyme linked immunosorbent assay
- female
- follow up
- genetic risk
- human
- human tissue
- longitudinal study
- major clinical study
- male
- Case-control study
- follow-up study
- amyotrophic lateral sclerosis
- cardiac troponin T
- neurofilament proteins
- amyotrophic-lateral-sclerosis
- inclusion-body myositis
- prognostic
- biomarker
- cardiomyopathy
- neurofilaments
- diagnosis
- heart
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Kläppe, U.
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Chamoun, S.
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Shen, Q.
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Finn, A.
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Evertsson, B.
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Zetterberg, Henr ...
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show more...
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Blennow, Kaj, 19 ...
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Press, R.
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Samuelsson, K.
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Månberg, Anna, 1 ...
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Fang, F.
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Ingre, C.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Amyotrophic Late ...
- By the university
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Royal Institute of Technology
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Karolinska Institutet
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University of Gothenburg