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Role of Cellular Me...
Role of Cellular Metabolism during Candida-Host Interactions
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- Pellon, Aize (författare)
- Kings Coll London, Fac Dent, Ctr Host Microbiome Interact, Oral & Craniofacial Sci, London, England.
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- Begum, Neelu (författare)
- Kings Coll London, Fac Dent, Ctr Host Microbiome Interact, Oral & Craniofacial Sci, London, England.
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- Sadeghi Nasab, Shervin Dokht (författare)
- Kings Coll London, Fac Dent, Ctr Host Microbiome Interact, Oral & Craniofacial Sci, London, England.
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- Harzandi, Azadeh (författare)
- Kings Coll London, Fac Dent, Ctr Host Microbiome Interact, Oral & Craniofacial Sci, London, England.
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- Shoaie, Saeed (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,Kings Coll London, Fac Dent, Ctr Host Microbiome Interact, Oral & Craniofacial Sci, London, England.
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- Moyes, David L. (författare)
- Kings Coll London, Fac Dent, Ctr Host Microbiome Interact, Oral & Craniofacial Sci, London, England.
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Kings Coll London, Fac Dent, Ctr Host Microbiome Interact, Oral & Craniofacial Sci, London, England Science for Life Laboratory, SciLifeLab (creator_code:org_t)
- 2022-01-28
- 2022
- Engelska.
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Ingår i: Pathogens. - : MDPI AG. - 2076-0817. ; 11:2
- Relaterad länk:
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https://doi.org/10.3...
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Microscopic fungi are widely present in the environment and, more importantly, are also an essential part of the human healthy mycobiota. However, many species can become pathogenic under certain circumstances, with Candida spp. being the most clinically relevant fungi. In recent years, the importance of metabolism and nutrient availability for fungi-host interactions have been highlighted. Upon activation, immune and other host cells reshape their metabolism to fulfil the energy-demanding process of generating an immune response. This includes macrophage upregulation of glucose uptake and processing via aerobic glycolysis. On the other side, Candida modulates its metabolic pathways to adapt to the usually hostile environment in the host, such as the lumen of phagolysosomes. Further understanding on metabolic interactions between host and fungal cells would potentially lead to novel/enhanced antifungal therapies to fight these infections. Therefore, this review paper focuses on how cellular metabolism, of both host cells and Candida, and the nutritional environment impact on the interplay between host and fungal cells.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- NATURVETENSKAP -- Biologi -- Ekologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Ecology (hsv//eng)
Nyckelord
- immunometabolism
- metabolism
- macrophages
- epithelial cells
- glycolysis
- glucose
- moonlighting proteins
- Candida albicans
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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