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Molecular Genetics ...
Molecular Genetics and Cytotoxic Responses to Titanium Diboride and Zinc Borate Nanoparticles on Cultured Human Primary Alveolar Epithelial Cells
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- Turkez, Hasan (författare)
- Ataturk Univ, Fac Med, Dept Med Biol, TR-25240 Erzurum, Turkey.
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- Arslan, Mehmet Enes (författare)
- Erzurum Tech Univ, Fac Sci, Dept Mol Biol & Genet, TR-25240 Erzurum, Turkey.
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- Tatar, Arzu (författare)
- Ataturk Univ, Fac Med, Dept Otorhinolaryngol, TR-25240 Erzurum, Turkey.
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- Ozdemir, Ozlem (författare)
- Erzurum Tech Univ, Fac Sci, Dept Mol Biol & Genet, TR-25240 Erzurum, Turkey.
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- Sonmez, Erdal (författare)
- Ataturk Univ, Grad Sch Nat & Appl Sci, Dept Nanosci & Nanoengn, Adv Mat Res Lab, TR-25240 Erzurum, Turkey.
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- Cadirci, Kenan (författare)
- Hlth Sci Univ, Erzurum Reg Training & Res Hosp, Dept Internal Med, TR-25240 Erzurum, Turkey.
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- Hacimuftuoglu, Ahmet (författare)
- Ataturk Univ, Med Fac, Dept Med Pharmacol, TR-25240 Erzurum, Turkey.
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- Ceylan, Bahattin (författare)
- Ataturk Univ, Fac Med, Dept Med Biol, TR-25240 Erzurum, Turkey.
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- Acikyildiz, Metin (författare)
- Kilis 7 Aralik Univ, Dept Chem, Fac Sci & Art, TR-79000 Kilis, Turkey.
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- Kahraman, Cigdem Yuce (författare)
- Ataturk Univ, Med Fac, Dept Med Genet, TR-25240 Erzurum, Turkey.
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- Geyikoglu, Fatime (författare)
- Ataturk Univ, Fac Arts & Sci, Dept Biol, TR-25240 Erzurum, Turkey.
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- Tatar, Abdulgani (författare)
- Ataturk Univ, Med Fac, Dept Med Genet, TR-25240 Erzurum, Turkey.
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- Mardinoglu, Adil (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England.
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Ataturk Univ, Fac Med, Dept Med Biol, TR-25240 Erzurum, Turkey Erzurum Tech Univ, Fac Sci, Dept Mol Biol & Genet, TR-25240 Erzurum, Turkey. (creator_code:org_t)
- 2022-03-22
- 2022
- Engelska.
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Ingår i: Materials. - : MDPI. - 1996-1944. ; 15:7
- Relaterad länk:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Titanium diboride (TiB2) and zinc borate (Zn3BO6) have been utilized in wide spectrum industrial areas because of their favorable properties such as a high melting point, good wear resistance, high hardness and thermal conductivity. On the other hand, the biomedical potentials of TiB2 and Zn3BO6 are still unknown because there is no comprehensive analysis that uncovers their biocompatibility features. Thus, the toxicogenomic properties of TiB2 and Zn3BO6 nanoparticles (NPs) were investigated on human primary alveolar epithelial cell cultures (HPAEpiC) by using different cell viability assays and microarray analyses. Protein-Protein Interaction Networks Functional Enrichment Analysis (STRING) was used to associate differentially expressed gene probes. According to the results, up to 10 mg/L concentration of TiB2 and Zn3BO6 NPs application did not stimulate a cytotoxic effect on the HPAEpiC cell cultures. Microarray analysis revealed that TiB2 NPs exposure enhances cellular adhesion molecules, proteases and carrier protein expression. Furthermore, Zn3BO6 NPs caused differential gene expressions in the cell cycle, cell division and extracellular matrix regulators. Finally, STRING analyses put forth that inflammation, cell regeneration and tissue repair-related gene interactions were affected by TiB2 NPs application. Zn3BO6 NPs exposure significantly altered inflammation, lipid metabolism and infection response activator-related gene interactions. These investigations illustrated that TiB2 and Zn3BO6 NPs exposure may affect different aspects of cellular machineries such as immunogenic responses, tissue regeneration and cell survival. Thus, these types of cellular mechanisms should be taken into account before the use of the related NPs in further biomedical applications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- titanium diboride
- zinc borate
- nanoparticles
- in vitro
- human primary alveolar epithelial cell cultures
- toxicogenomic responses
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Turkez, Hasan
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Arslan, Mehmet E ...
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Tatar, Arzu
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Ozdemir, Ozlem
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Sonmez, Erdal
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Cadirci, Kenan
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Hacimuftuoglu, A ...
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Ceylan, Bahattin
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Acikyildiz, Meti ...
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Kahraman, Cigdem ...
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Geyikoglu, Fatim ...
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Tatar, Abdulgani
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Mardinoglu, Adil
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