Mitochondrial Targeting Probes, Drug Conjugates, and Gene Therapeutics

• Mitochondria represent an important drug target for many phatology, including neurodegeneration, metabolic disease, heart failure, ischemia-reperfusion injury, and cancer. Mitochondrial dysfunctions are caused by mutation in mitochondrial DNA or in nuclear genes encoding mitochondrial proteins. Cell-penetrating peptides (CPPs) have been employed to overcome biological barriers, target this organelle, and therapeuticaly restore mitochondrial functions. Here, we describe recent methods used to deliver oligonucleotides targeting mitochondrial protein by using mitochondrial penetrating peptides. In particular, we highlight recent advances of formulated peptides/oligonucleotides nanocomplexes as a proof-of-principle for pharmaceutical form of peptide-based therapeutics.

Ämnesord

NATURVETENSKAP  -- Kemi -- Fysikalisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Physical Chemistry (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)

Nyckelord

Intracellular delivery

mitFects

Mitochondria

Nanocarriers

Nanoparticles

1 methyl 2 pyrrolidinone

amino acid

antisense oligonucleotide

cell penetrating peptide

mitFects peptide

mitochondrial protein

n

n dimethylformamide

nanoparticle

stearic acid

unclassified drug

drug

oligonucleotide

clinical feature

clinical trial (topic)

complex formation

confocal microscopy

disorders of mitochondrial functions

drug conjugation

drug delivery system

drug development

drug targeting

gene targeting

gene therapy

HeLa cell line

high performance liquid chromatography

human

human cell

in vitro study

internalization (cell)

mitochondrial gene

peptide library

peptide synthesis

protein analysis

protein purification

synthesis

zeta potential

genetics

mitochondrion

Cell-Penetrating Peptides

Drug Delivery Systems

Mitochondrial Proteins

Oligonucleotides

Pharmaceutical Preparations

Publikations- och innehållstyp

ref (ämneskategori)

kap (ämneskategori)