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Molecular dynamics ...
Molecular dynamics simulations indicate that DNA bases using graphene nanopores can be identified by their translocation times
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Shi, C. (författare)
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Kong, Z. (författare)
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Sun, T. (författare)
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- Liang, Lijun (författare)
- KTH,Teoretisk kemi och biologi,Department of Chemistry and Soft Matter Research Center, Zhejiang University, Hangzhou 310027, People's Republic of China
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Shen, J. (författare)
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Zhao, Z. (författare)
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Wang, Q. (författare)
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- Kang, Zhengzhong (författare)
- KTH,Teoretisk kemi och biologi,Department of Chemistry and Soft Matter Research Center, Zhejiang University, Hangzhou 310027, People's Republic of China
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- Ågren, Hans (författare)
- KTH,Teoretisk kemi och biologi
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Tu, Y. (författare)
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(creator_code:org_t)
- 2015
- 2015
- Engelska.
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Ingår i: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 5:13, s. 9389-9395
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The improvement of the resolution of DNA sequencing by nanopore technology is very important for its real-life application. In this paper, we report our work on using molecular dynamics simulation to study the dependence of DNA sequencing on the translocation time of DNA through a graphene nanopore, using the single-strand DNA fragment translocation through graphene nanopores with diameters down to ∼2 nm as examples. We found that A, T, C, and G could be identified by the difference in the translocation time between different types of nucleotides through 2 nm graphene nanopores. In particular, the recognition of the graphene nanopore for different nucleotides can be greatly enhanced in a low electric field. Our study suggests that the recognition of a graphene nanopore by different nucleotides is the key factor for sequencing DNA by translocation time. Our study also indicates that the surface of a graphene nanopore can be modified to increase the recognition of nucleotides and to improve the resolution of DNA sequencing based on the DNA translocation time with a suitable electric field.
Ämnesord
- NATURVETENSKAP -- Kemi -- Teoretisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Theoretical Chemistry (hsv//eng)
Nyckelord
- DNA
- DNA sequences
- Electric fields
- Gene encoding
- Graphene
- Molecular dynamics
- Nanopores
- Nucleotides
- DNA basis
- DNA Sequencing
- DNA translocation
- Key factors
- Molecular dynamics simulations
- Real-life applications
- Single strand DNA
- Bioinformatics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Shi, C.
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Kong, Z.
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Sun, T.
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Liang, Lijun
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Shen, J.
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Zhao, Z.
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visa fler...
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Wang, Q.
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Kang, Zhengzhong
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Ågren, Hans
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Tu, Y.
-
visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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och Teoretisk kemi
- Artiklar i publikationen
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RSC Advances
- Av lärosätet
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Kungliga Tekniska Högskolan