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Synthesis and struc...
Synthesis and structural study of new saturated isoindol-1-one derivatives
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Csende, F. (författare)
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- Szabó, Zoltan, Associate professor (författare)
- Alkaloida Chemical Company Ltd., 4440 Tiszavasvári, Hungary
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Stájer, G. (författare)
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Alkaloida Chemical Company Ltd, 4440 Tiszavasvári, Hungary (creator_code:org_t)
- The Japan Institute of Heterocyclic Chemistry, 1993
- 1993
- Engelska.
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Ingår i: Heterocycles. - : The Japan Institute of Heterocyclic Chemistry. - 0385-5414 .- 1881-0942. ; 36:8, s. 1809-1821
- Relaterad länk:
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https://urn.kb.se/re...
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visa fler...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Condensation of 2-p-toluoylcyclohexanecarboxylic acid (1a,b) with primary amines gave the corresponding hexahydroisoindol-1-ones (2a-g) in good yield. The octahydro derivatives (4a-g) were prepared from cis- and trans-hexahydro-1(2H)-phthalazinone (3a,b) by reduction with zinc-hydrochloric acid via ring contraction. Stereoselective synthesis of cis-N-phenyloctahydroisoindol-1-one (4h) was performed starting from 2b by reduction with magnesium-methanol at room temperature. Configurational assignments of cis and trans isomers were based on 1H-and 13C-nmr spectroscopic studies.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
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