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Assessment of the n...
Assessment of the neuroprotective potential of d-cycloserine and l-serine in aluminum chloride-induced experimental models of Alzheimer's disease : In vivo and in vitro studies
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- Tozlu, OEzlem OEzdemir (författare)
- Erzurum Tech Univ, Dept Mol Biol & Genet, Erzurum, Turkey.
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- Tuerkez, Hasan (författare)
- Ataturk Univ, Dept Med Biol, Fac Med, Erzurum, Turkey.
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- Okkay, Ufuk (författare)
- Ataturk Univ, Dept Med Pharmacol, Fac Med, Erzurum, Turkey.
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- Ceylan, Onur (författare)
- Ataturk Univ, Dept Med Pathol, Fac Med, Erzurum, Turkey.
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- Bayram, Cemil (författare)
- Ataturk Univ, Dept Med Pharmacol, Fac Med, Erzurum, Turkey.
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- Hacimueftueoglu, Ahmet (författare)
- Ataturk Univ, Dept Med Pharmacol, Fac Med, Erzurum, Turkey.
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- Mardinoglu, Adil (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kings Coll London, Ctr Host Microbiome Interact, Fac Dent, Oral Craniofacial Sci, London, United Kingdom.
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Erzurum Tech Univ, Dept Mol Biol & Genet, Erzurum, Turkey Ataturk Univ, Dept Med Biol, Fac Med, Erzurum, Turkey. (creator_code:org_t)
- 2022-09-08
- 2022
- Engelska.
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Ingår i: Frontiers in Nutrition. - : Frontiers Media SA. - 2296-861X. ; 9
- Relaterad länk:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Alzheimer's disease (AD) is a neurodegenerative disease characterized by the accumulation of amyloid-beta (A beta) plaques and neurofibrillary tangles in the brain accompanied by synaptic dysfunction and neurodegeneration. No effective treatment has been found to slow the progression of the disease. Therapeutic studies using experimental animal models have therefore become very important. Therefore, this study aimed to investigate the possible neuroprotective effect of D-cycloserine and L-serine against aluminum chloride (AlCl3)-induced AD in rats. Administration of AlCl3 for 28 days caused oxidative stress and neurodegeneration compared to the control group. In addition, we found that aluminum decreases alpha -secretase activity while increasing beta -secretase and gamma -secretase activities by molecular genetic analysis. D-cycloserine and L-serine application resulted in an improvement in neurodegeneration and oxidative damage caused by aluminum toxicity. It is believed that the results of this study will contribute to the synthesis of new compounds with improved potential against AlCl3-induced neurodegeneration, cognitive impairment, and drug development research.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer's disease
- aluminum
- D-cycloserine
- L-serine
- neuroprotective
- neuro-nutrient
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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