The neuropeptide landscape of human prefrontal cortex

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The neuropeptide landscape of human prefrontal cortex

Zhong, Wen (författare): Linköpings universitet,KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden.;Linköping Univ, Dept Biomed & Clin Sci BKV, Sci Life Lab, S-58225 Linköping, Sweden.,Avdelningen för cellbiologi,Medicinska fakulteten,Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden;Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden

Barde, Swapnali (författare): Karolinska Institutet

Mitsios, Nicholas (författare): Karolinska Institutet

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Adori, Csaba (författare): Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden.,Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden

Oksvold, Per (författare): KTH,Science for Life Laboratory, SciLifeLab,Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden

von Feilitzen, Kalle (författare): KTH,Proteinteknologi,Science for Life Laboratory, SciLifeLab,Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology,Stockholm, Sweden

O'Learyd, Liam (författare): McGill Univ, Dept Psychiat, Montreal, PQ, Canada.;Douglas Hosp, McGill Grp Suicide Studies, Montreal, PQ, Canada.,Department of Psychiatry, McGill University, Montreal, Canada; McGill Group for Suicide Studies, Douglas Hospital Research Centre, Montreal, Canada

Csiba, Laszlo (författare): Univ Debrecen, Dept Neurol, Fac Med, H-4032 Debrecen, Hungary.,Department of Neurology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

Hortobagyi, Tibor (författare): Univ Szeged, Inst Pathol, Fac Med, H-6720 Szeged, Hungary.,Institute of Pathology, Faculty of Medicine, University of Szeged, Hungary

Szocsics, Peter (författare): Semmelweis Univ, Szentagothai Janos Doctoral Sch Neurosci, H-1085 Budapest, Hungary.;Eotvos Lorand Res Network ELKH, Inst Expt Med, Human Brain Res Lab, H-1052 Budapest, Hungary.,Szentágothai János Doctoral School of Neuroscience, Semmelweis University, 1085 Budapest, Hungary;Human Brain Research Laboratory, Institute of Experimental Medicine, Eötvös Loránd Research Network (ELKH), Budapest, Hungary

Mechawar, Naguib (författare): McGill Univ, Dept Psychiat, Montreal, PQ, Canada.;Douglas Hosp, McGill Grp Suicide Studies, Montreal, PQ, Canada.,Department of Psychiatry, McGill University, Montreal, Canada;McGill Group for Suicide Studies, Douglas Hospital Research Centre, Montreal, QC H4H 1R3, Canada

Magloczky, Zsofia (författare): Eotvos Lorand Res Network ELKH, Inst Expt Med, Human Brain Res Lab, H-1052 Budapest, Hungary.,Human Brain Research Laboratory, Institute of Experimental Medicine, Eötvös Loránd Research Network (ELKH), Budapest, Hungary

Renner, Eva (författare): Semmelweis Univ, Human Brain Tissue Bank, H-1085 Budapest, Hungary.,Human Brain Tissue Bank, Semmelweis University, Budapest, Hungary

Palkovits, Miklos (författare): Semmelweis Univ, Human Brain Tissue Bank, H-1085 Budapest, Hungary.,Human Brain Tissue Bank, Semmelweis University, Budapest, Hungary

Uhlén, Mathias (författare): KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden,Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden;Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden

Mulder, Jan (författare): Karolinska Institutet

Hokfelt, Tomas (författare): Karolinska Institutet

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(creator_code:org_t)

2022-08-10
2022
Engelska.
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 119:33

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Tidskriftsartikel (refereegranskat)

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Human prefrontal cortex (hPFC) is a complex brain region involved in cognitive and emotional processes and several psychiatric disorders. Here, we present an overview of the distribution of the peptidergic systems in 17 subregions of hPFC and three reference cortices obtained by microdissection and based on RNA sequencing and RNA-scope methods integrated with published single-cell transcriptomics data. We detected expression of 60 neuropeptides and 60 neuropeptide receptors in at least one of the hPFC subregions. The results reveal that the peptidergic landscape in PFC consists of closely located and functionally different subregions with unique peptide/transmitter- related profiles. Neuropeptide-rich PFC subregions were identified, encompassing regions from anterior cingulate cortex/orbitofrontal gyrus. Furthermore, marked differences in gene expression exist between different PFC regions (>5-fold; cocaine and amphetamine-regulated transcript peptide) as well as between PFC regions and reference regions, for example, for somatostatin and several receptors. We suggest that the present approach allows definition of, still hypothetical, microcircuits exemplified by glutamatergic neurons expressing a peptide cotransmitter either as an agonist (hypocretin/orexin) or antagonist (galanin). Specific neuropeptide receptors have been identified as possible targets for neuronal afferents and, interestingly, peripheral blood-borne peptide hormones (leptin, adiponectin, gastric inhibitory peptide, glucagon-like peptides, and peptide YY). Together with other recent publications, our results support the view that neuropeptide systems may play an important role in hPFC and underpin the concept that neuropeptide signaling helps stabilize circuit connectivity and fine-tune/modulate PFC functions executed during health and disease.

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Av författaren/redakt...: Zhong, Wen; Barde, Swapnali; Mitsios, Nichola ...; Adori, Csaba; Oksvold, Per; von Feilitzen, K ...; visa fler...; O'Learyd, Liam; Csiba, Laszlo; Hortobagyi, Tibo ...; Szocsics, Peter; Mechawar, Naguib; Magloczky, Zsofi ...; Renner, Eva; Palkovits, Miklo ...; Uhlén, Mathias; Mulder, Jan; Hokfelt, Tomas; visa färre...

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Av lärosätet: Kungliga Tekniska Högskolan; Linköpings universitet; Karolinska Institutet

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The neuropeptide landscape of human prefrontal cortex

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